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Biotech / Medical : MEDX ... anybody following? -- Ignore unavailable to you. Want to Upgrade?

To: Icebrg who wrote (767)	11/18/2003 1:43:14 PM
From: tuck	Read Replies (1) \| Respond to of 2240

I have no idea if MEDX is doing anything in this area, but the lead author of this study is apparently employed by them, so . . . >>Published online before print November 18, 2003 Proc. Natl. Acad. Sci. USA, 10.1073/pnas.2436350100 Cell Biology Rab27b is associated with fusiform vesicles and may be involved in targeting uroplakins to urothelial apical membranes Yanru Chen , Xuemei Guo , Fang-Ming Deng , Feng-Xia Liang , Wenyu Sun , Mindong Ren , Tetsuro Izumi ¶, David D. Sabatini , Tung-Tien Sun \|\|, and Gert Kreibich Departments of Cell Biology, Dermatology, \|\|Pharmacology, and Urology, New York University School of Medicine, 550 First Avenue, New York, NY 10016; ¶Department of Molecular Medicine, Gunma University, Maebashi 371-8510, Japan; and Medarex, Bloomsbury, Inc., Princeton, NJ 08540 Contributed by David D. Sabatini, October 2, 2003 The terminally differentiated umbrella cells of bladder epithelium contain unique cytoplasmic organelles, the fusiform vesicles, which deliver preassembled crystalline arrays of uroplakin proteins to the apical cell surface of urothelial umbrella cells. We have investigated the possible role of Rab proteins in this delivery process, and found Rab27b to be expressed at an extraordinary high level (0.1% of total protein) in urothelium, whereas Rab27b levels were greatly reduced (to <5% of normal urothelium) in cultured urothelial cells, which synthesized only small amounts of uroplakins and failed to form fusiform vesicles. Immuno-electron microscopy showed that Rab27b was associated with the cytoplasmic face of the fusiform vesicles, but not with that of the apical plasma membrane. The association of Rab27b with fusiform vesicles and its differentiation-dependent expression suggest that this Rab protein plays a role in regulating the delivery of fusiform vesicles to the apical plasma membrane of umbrella cells.<< Cheers, Tuck