To: RealMuLan who wrote (2315 ) 12/31/2003 5:47:15 PM From: Henry Niman Respond to of 6370 The report below indicates that the SARS samples have gone to independent lab(s) for confirmation by WHO, but WHO is saying confirmation will take "about a week", further confirming that the real issue is the epi-link and not the lab data. Results from media reports indicate that several labs in Guangzhou and Beijing have satisfied the "lab confirmation" criteria several times over. PCR positives have been obtained by multiple labs, and antibody data have shown that the sera is positive, is increasing in titer, and sero conversion has happened. For confirmation, only one of the 4 criteria listed above have been met. It seems that the only criteria that has not appeared in media reports is isolation of virus. However, virus isolation is relatively rare. I believe that all Canadian isolates are from Toronto I or Vancouver. No virus has been isolated from Toronto II. Similarly, although over 9000 were diagnosed with SARS, the number of isolates worldwide is in the low 100's. The issue really is the epi-link, and if the SARS is from a re-activated virus (based on the report that the patient was a suspect SARS case last March), then there may be no epi-link to find.straitstimes.asia1.com.sg JAN 1, 2004 Samples from Sars suspect sent to WHO's labs It will be another week before a formal confirmed diagnosis can be made about the Chinese patient in Guangzhou By Mary Kwang HONG KONG CORRESPONDENT SAMPLES taken from a suspected Sars patient in Guangzhou are expected to reach a World Health Organisation (WHO) network of laboratories by today, after China gave the green light for tests to be conducted abroad. A Manila-based WHO spokesman, Mr Charles Raby, said yesterday that the case could be confirmed only if tests prove positive. This would mean waiting another week for a formal confirmed diagnosis of the 32-year-old suspected Sars patient. Mr Roy Wadia, a WHO spokesman in Beijing, who reiterated that tests carried out so far in China produced unclear results, said: 'We are actually hoping that the more testing that is done in different places, the better we are able to arrive at a conclusion.' He said he did not know yet which overseas laboratory the samples would be sent to. In the Guangdong capital, Professor Zhong Nanshan, director of the Guangzhou Institute of Respiratory Diseases, said: 'Mutual corroboration is very good. We need international cooperation.' He was speaking to reporters after a meeting yesterday with a visiting WHO team. He said Guangdong medical experts had found Sars antibodies in the patient, supporting statements made a day earlier by provincial health officials that the man had contracted the disease. He added that despite several repeated tests, it was difficult to confirm the diagnosis as experts were stumped by how the patient was infected.