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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?


To: Robert K. who wrote (16673)2/28/2004 12:10:40 AM
From: Robert K.  Respond to of 17367
 
J Drugs Dermatol. 2004 Jan-Feb;3(1):77-9. Related Articles, Links

Generalized pustular psoriasis following withdrawal of efalizumab.

Gaylor ML, Duvic M.

Louisiana State University Health Sciences Center, New Orleans, USA.

Efalizumab is one of the new biologic therapies targeting T-lymphocyte activity for the treatment of chronic plaque psoriasis. Common adverse effects include headaches, nonspecific infection, nausea, chills, and fever. Rebound of psoriasis following discontinuation of the drug has been reported. Relapse events can manifest as recurrent plaque psoriasis, guttate psoriasis, psoriatic erythroderma, and pustular psoriasis. We report a second case of withdrawal flare resulting in generalized pustular psoriasis.