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Biotech / Medical : NPSP NPS Pharmaceutical -- Ignore unavailable to you. Want to Upgrade?

To: tuck who wrote (203)	3/11/2004 5:35:42 PM
From: Icebrg	Respond to of 363

>>Here's a quick look at the supposed advantages of the competing mAB ABGX is developing (with thanks to Erik for the summation):>> In the 10K, which was issued today Abgenix writes the following. ABX-PTH, which targets and neutralizes the action of parathyroid hormone in preclinical studies, is being developed for the treatment of secondary hyperparathyroidism (SHPT). This fully human antibody has a novel mechanism of action that, in preclinical studies, neutralizes PTH by directly lowering serum levels of free PTH without increasing serum calcium or phosphate, as some current therapies do. We believe that ABX-PTH could provide a significant therapeutic advance for the SHPT population by directly reducing bioactive PTH levels, rather than relying on the indirect mechanisms provided by current therapies.