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Biotech / Medical : Biotech Valuation -- Ignore unavailable to you. Want to Upgrade?

To: Biomaven who wrote (11085)	3/31/2004 11:48:29 AM
From: tom pope	Read Replies (1) \| Respond to of 52153

I saw that weirdness too, but it was expected, for some reason (probably a weird one) Almost all of these responders were in the 2 lowest dosage groups, confirming laboratory studies that showed a greater anti-tumor effect for ovarian cancer at lower dosages for phenoxodiol Low float thinly traded stocks with huge spreads can sometimes be advantageous if you're trying to accumulate. Ultra low ball bids sometimes get filled.

To: Biomaven who wrote (11085)	3/31/2004 12:44:23 PM
From: zeta1961	Respond to of 52153

<<But this isn't a traditional cytotoxic drug, so maybe we should expect a little weirdness.>> I've been trying to follow MSHL since hearing about it here...we are used to more is better...in many cases it is...but these new small molecules are working on pathways never studied before in the clinical setting...so, anything goes...we have to remember that the body has...quite simplistically...2 systems by which it regulates itself...a postive feedback loop and a negative feedback loop...for example...when a patient is hypothyroid...the pituitary gland secretes more thyroid stimulating hormone to try to make the thyroid produce more...when one is given thyroid hormone the pituitary and thyroid gland say..."Hey, got enough no need to produce"...which renders the thyroid gland non-functioning and reliant on exogenous hormone... When one is dehydrated, the body puts out hormones to retain sodium, decrease it's urine output...but when this system goes awry as in brain trauma and edema or even diabetic ketoacidosis...it "forgets" and puts out puts out too much diuretic hormone...causing even more severe dehydration... I know the scientists can explain this more eloquently...but just some thoughts as to why dosages of meds can have what we would characterize as paradoxic effects... Other examples...tricyclic antidepressants...low doses treat anxiety, night time bladder control for kids, migraines...whereas higher doses treat the depressive component...high dose naltrexone inhibits endorphin release...low dose stimulates...this is what PTIE is finding with Oxytrex... Very fascinating stuff...my friends in college always teased me about becoming a mad-drug scientist one day because of my at times obsessive fascination with how drugs interact within the human body...their prediction did not come true:) Zeta