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To: BubbaFred who wrote (49477)	5/5/2004 12:41:36 AM
From: BubbaFred	Respond to of 74559

Caliper Upgrades Microfluidics PlatformThe LabChip 3000 Drug Discovery System is both smaller and simpler than its predecessor Courtesy of Caliper Life Sciences Making its latest foray into the microfluidics ring, Hopkinton, Mass.-based Caliper Life Sciences (www.caliperls.com) has introduced the new LabChip 3000 Drug Discovery System, a second-generation tool that builds on the foundation laid by its predecessor, the Caliper 250. Intended for high-throughput drug-detection studies, including a range of assay applications such as kinases, proteases, and phosphatases, the LabChip 3000 is both smaller and easier to use than previous systems. "There's been a lot of industrial design into this project, looking very much into its usability and reliability," says Yvonne Linney, Caliper's senior director of marketing and product management, adding that user input factored greatly into the new design. Among the most basic upgrades incorporated into the LabChip 3000 is an easy-access door allowing users to better handle their chip and plate samples. The platform also includes modern optics with longer laser lifetimes and can run Caliper's own LabChips, both four-sipper and 12-sipper, as well as 96-well and 384-well microplates. An automated 60-microplate handler and LabChip cartridges can be used to increase throughput, with a maximum unattended run time of about 16 hours. Caliper's sipper-based LabChips rely on a capillary tube of fused silica to transfer nanoliter-volume samples from microplate wells to the channels of a microfluidic chip-like device. Built for automation, a single sipper chip can be used repeatedly to analyze thousands of samples. A low-throughput planar LabChip requires users to manually pipette chemical reagents into its reservoirs. The LabChip 3000 is modular to suit laboratory tastes, and is available as a low-cost assay-development system that can be upgraded to the complete high-end screening system if needed. The latter configuration includes environmental temperature and humidity controls for sample storage and automation, but both versions offer a wide range of fluorescence excitation and detection wavelengths. the-scientist.com