To: tuck who wrote (488 ) 8/2/2004 11:46:31 AM From: nigel bates Respond to of 625 Evolutec Group PLC 2 August 2004 EVOLUTEC GROUP PLC First Day of Dealings on the Alternative Investment Market ('AIM') Evolutec Group plc ('Evolutec' or 'the Company') (LSE: EVC), the biopharmaceutical company developing novel products for the treatment of allergic, inflammatory and autoimmune diseases, is pleased to announce its flotation on the Alternative Investment Market of the London Stock Exchange ('AIM') today. • Evolutec isolates potential drugs from the saliva of ticks, which contain an array of novel molecules that suppress mammalian immune responses. These molecules offer the potential of treating human diseases caused by over-responsiveness of the immune system and have evolved over millions of years to enable ticks to take blood from their hosts. • The Company's lead product, rEV131, is a recombinant histamine-binding protein. The Directors believe rEV131 is the only product in clinical trials that impacts the recently discovered H4 receptor. rEV131 has completed preliminary phase II clinical trials in allergic conjunctivitis, rhinitis and ocular inflammation. • £6.0 million (gross) was raised for Evolutec via a Placing at the price of 125 pence per share and via the exercise of outstanding warrants. • Collins Stewart is the Company's nominated advisor and broker. Elixir Securities acted as research consultants. • On Admission, the market capitalisation of Evolutec at the Placing Price will be £12.7 million (post new money). • The proceeds will be used to fund proof of concept phase II clinical trials in allergic rhinitis and phase II and III trials in post-cataract surgery for rEV131 and to fund the development of the Company's pipeline. • ISIS Asset Management plc, one of Evolutec's principal shareholders, has invested £1.8 million in the Fundraising. • Evolutec's directors have invested £217,500 in the Fundraising. FUNDRAISING STATISTICS Placing Price 125p per share Number of Ordinary Shares placed on behalf of the Group 4,560,000 shares Gross proceeds of the Placing £5.7 million Proceeds from exercise of Warrants £0.3 million Net proceeds available to the Company £5.1 million Market capitalisation at the Placing Price on Admission £12.7 million Issued Share Capital after issue 10,198,048 shares Commenting on the announcement, Dr Mark Carnegie Brown, Evolutec's Chief Executive Officer, said: 'I am delighted that Evolutec has joined AIM today. Our support from investors has been extremely strong - both from new and existing institutions. We look forward to building value for our shareholders and reporting positive news back to the market.' ENDS For further information: Evolutec 01865 784070 Mark Carnegie Brown, Chief Executive Officer Nicholas Badman, Chief Financial Officer www.evolutec.co.uk