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Pastimes : SARS - what next? -- Ignore unavailable to you. Want to Upgrade?

To: Maurice Winn who wrote (905)	8/20/2004 5:36:23 AM
From: Henry Niman	Respond to of 1070

Bloomberg is reporting on H5N1 isolated from swine in China. However, the swine H5N1 sequences have been available for over a month recombinomics.com and human/swine sequences have been found in human and avian H5N1 isolates (via recombination).

To: Maurice Winn who wrote (905)	8/20/2004 7:11:53 AM
From: Henry Niman	Respond to of 1070

Maurice, Last season the human cases of avian flu first appeared in ProMed reports in December. There may have been earlier cases, but the first confirmed deaths in humans from avian flu was Dec, which paralleled the animal outbreaks. The flu in Asia was most widespread in Jan/Feb and then waned in the spring. It seems to be starting early, recombinomics.com although this may be due to more awareness. However, deaths have been reported this month in Vietnam, and there are reports of animal infections from China, Thailand, Vietnam, and now Malaysia. The virus continues to pick up Human/swine sequences and it is expanding its host range (via H5N1 and H9N2 isolates). I expect the virus to be more widespread and deadly this season. It has become extremely unstable geneticly, and more recombinations are expected

To: Maurice Winn who wrote (905)	8/20/2004 10:31:17 AM
From: Henry Niman	Respond to of 1070

Maurice, I have put up some comments on avian flu evolution (via recombination) and its expanded host range recombinomics.com NY Times (International Herald Tribune) is also covering the news of H5N1 in swine, but recombination between avian and mammalian (human or swine) sequences has already happened.

To: Maurice Winn who wrote (905)	8/20/2004 11:46:10 AM
From: Henry Niman	Respond to of 1070

Now questions are being raised about the infectivity of the swine H5N1 isolates. However, the isolates from dead patients in Vietnam and Thailand have molecular signatures recombinomics.com

To: Maurice Winn who wrote (905)	10/5/2004 3:39:27 PM
From: Henry Niman	Respond to of 1070

Mq, I looks like the H5N1 virus is evolving. Now it is presenting as Dengue Fever, recombinomics.com which is sure to cause problems. Virus is evolving while Chiron can't even get an FDA approved product to market. Looks like the virus has taken a clear lead.