Silicon Investor (SI) -- The First Internet Community

STOCKTALK

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor. We ask that you disable ad blocking while on Silicon Investor in the best interests of our community. If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.

Strategies & Market Trends : The Epic American Credit and Bond Bubble Laboratory -- Ignore unavailable to you. Want to Upgrade?

To: patron_anejo_por_favor who wrote (22347)	11/23/2004 7:11:17 PM
From: Henry Niman	Respond to of 110194

You need to check out the latest update. Today NPR is running a piece on a CDC experiment to create a pandemic strain of flu so they will know what to look for. Unfortunately, the plan is fundamentally flawed recombinomics.com They are STILL looking for re-assortment, which is not how pandemic viruses emerge and evolve. Viruses evolve quickly via recombination.

To: patron_anejo_por_favor who wrote (22347)	11/24/2004 6:09:50 AM
From: Henry Niman	Respond to of 110194

Here is the latest update, There is more media coverage on NIAID flu sequencing project. I have provided more details on how viruses use recombination to jump species recombinomics.com which of course leads to a flu pandemic.

To: patron_anejo_por_favor who wrote (22347)	11/24/2004 7:43:10 AM
From: Henry Niman	Respond to of 110194

Reassortment and recombination briefly described: Both reassortment and recombination have been known for some time, but most who study influenza don't realize that the chief driver of rapid evolution is recombination, which is why the concept is a paradigm shift recombinomics.com and the concept and applications are very patentable recombinomics.com Here is a quick summary. Re-assortment just re-shuffles genes. The flu virus has 8 genes and if two viruses infect the same cell, when the genes are package up there can be re-shuffling so gene 1 comes from virus A while gene 2 comes from virus B, etc. Thus the emerging virus has a new combination of genes. This can be seen in the serotypes, which just use 2 of the 8 genes. Thus, H3N2, H5N2, H7N2, H9N2 are 4 distinct serotypes. All have N2 but it is packaged with 4 different H genes to represent these 4 serotpes. Although all 4 N2s are closer to each other than to N1s, they really have some differences. Most influenza virologists would say the N2s are different because they mutated, but those virologists would be wrong. The N2s are different because when two viruses infect the same cell not only can the genes reassort, but they can also recombine. That happens when the gene copying machinery starts copying gene 1 from virus A and then finishes copying gene1 from virus B. In that case gene 1 is a NEW gene (its a chimera between the two gene 1s of the two viruses). The copying enzymes (polymerase) can actually hop back and forth many times (the process is called homologous recombination), and each time they create a NEW gene (and they can actually do this for all 8 genes creating 8 new genes). That's what viruses do. The evolve by quickly making new genes. That's what the 1918 pandemic virus did. That's what the H5N1 virus in Asia did. That's what the next pandemic virus will do. That's NOT what WHO and the CDC are looking for. They are looking for reassortments and can't figure out why they can't find them (while the virus is recombining every season).

To: patron_anejo_por_favor who wrote (22347)	11/25/2004 1:46:36 AM
From: Henry Niman	Read Replies (1) \| Respond to of 110194

The latest is from Reuters. They warning of the looming flu pandemic, repeat numbers using a case fatality rate of 1% (gross underestimate) and say that there is no evidence of H5N1 mating and mutating in mammalian hosts (which is simply wrong) recombinomics.com

To: patron_anejo_por_favor who wrote (22347)	11/25/2004 12:12:11 PM
From: Henry Niman	Respond to of 110194

I've put up a new update that even WHO and CDC should be able to understand recombinomics.com They keep talking about reassortment between H3N2 (human) and H5N1 (avian) leading to a pandemic strain. This pandemic strain would be H3N1, but there has never been a documented case of human H3N1 (probably due to some heavy duty selection agains such a reassorted virus). However, H5N1 recombines all the time (as did the 1918 pandemic strain), which is why it is killing 70-80% of the people infected in Thailand and Vietnam. recombinomics.com