To: MJ who wrote (2323 ) 11/29/2004 1:50:24 AM From: Walkingshadow Respond to of 8752 Hi MJ, I think a lot of the interest in ALNY has to do with the fact that they are taking the lead into clinical trials with RNAi. The macular degeneration trial should begin any time now, and there are several more that I am aware of that are gearing up to begin early next year. I expect this is only the beginning. Wall Street doesn't even know what RNAi stands for. Yet. Once they discover that, I think this will play out the same way we saw with genomo-momo, nano-nano momo, and stem cell momo. The mo-mo crowd knows they can easily overhype anything that is cutting-edge, exotic, not easily understood by Joe Sixpack (or Joe Analyst), and hints at the possibility of major advances. RNAi has all these key features. But another ingredient is needed: a float they can readily push around. And that requires as few trading shares as possible, and a low stock price. ALNY and RNAi have floats of 11 to 12 million shares, so at current prices, the entire trading float is worth $36 million (RNAi) to $72 million (ALNY). Not ideal, but not bad. For comparison purposes, when they really jumped on TZOO, it was trading at about $25/share, with a microfloat of 2.1 million. Multiply one by the other and you get about $52 million. So, I'd say RNAi and ALNY both fall roughly within range in that regard. There's one more thing to consider here, and that is the shorts. The mo-mo crowd favors highly shorted stocks because it amplifies upside through short-squeezes, and blunts downside because of short profit-taking. Not surprisingly then, the mo-mo favorite TZOO is one of the most heavily shorted stocks; 69% of the float is shorted. But ALNY and RNAI have vanishingly small short interest (2% of the float or less). So that is not a plus. But all in all, I think the mo-mo crowd will eventually bite, I just don't know exactly when that might be. My guess is sometime in the next 3 months or so, but it could be much sooner if there is some kind of catalyst. When you start seeing a huge ramp-up in volume of stocks like ALNY and RNAI, then you know the mo-mo feeding frenzy has begun. We have seen some nibbles in volume so far, at least with ALNY. The 3 month average of the daily volume is 45,000, but the 10 day average of daily volume is triple that at 135,000. For RNAI, there is just a slight increase at best. I suspect these volumes will exceed 1 million in the not-too-distant future, and could go well beyond that. JMVHO...... T