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To: Jim McMannis who wrote (22585)	11/29/2004 9:55:11 PM
From: Henry Niman	Read Replies (1) \| Respond to of 110194

It looks like WHO didn't like my calculation of case mortality rates. Between this morning's story in the International Herald Tribune recombinomics.com and this evenings New York Times recombinomics.com they brought out MANY new quotes and I lost my PhD degree.

To: Jim McMannis who wrote (22585)	11/29/2004 11:43:04 PM
From: Henry Niman	Respond to of 110194

For those officianados of pandemic flu, WHO, and control of the news, there actually are FOUR versions of NY Times story coming out tomorrow (it is the shortest of the four). I have all 4 (2 International Herald Tribune and 2 New York Times) linked at recombinomics.com

To: Jim McMannis who wrote (22585)	12/2/2004 8:58:08 PM
From: Henry Niman	Respond to of 110194

I will be on talk radio tomorrow morning at 11:05 AM EST to talk about the NY Times article (all four versions are linked at recombinomics.com including case fatality rates. The talk show is from 10-1 and I am not sure if they will be talking about pandemic FLU for the full three hours. It will be broadcast live at 1360wptt.com Just click on "listen live" (you may have to download a piece of audio software to listen, but I think it also allows you to capture the audio - the download window pops up when you click on listen live) The background of the host, Lynn Cullen, (and call in number) is at 1360wptt.com

To: Jim McMannis who wrote (22585)	12/3/2004 3:49:50 AM
From: Henry Niman	Read Replies (1) \| Respond to of 110194

The patient in France developed flu-like symptoms 48 hours before boarding his flight from Vietnam to France recombinomics.com Lab results expected shortly.

To: Jim McMannis who wrote (22585)	12/4/2004 5:47:40 PM
From: Henry Niman	Respond to of 110194

Newt Gingrich calling for congressional hearings on avian flu threat recombinomics.com

To: Jim McMannis who wrote (22585)	12/4/2004 9:47:59 PM
From: Henry Niman	Respond to of 110194

I'm not sure what I am missing here, but it would seem that H1N1 from 1933 in swine in 2004 would be a MAJOR concern recombinomics.com

To: Jim McMannis who wrote (22585)	12/6/2004 8:10:53 AM
From: Henry Niman	Respond to of 110194

Jim, More data on the H1N1 from Korea is linked to recombinomics.com Here are some of the numbers regarding the H1 and N1 There are two H1N1 isolates in 2004 from pigs. At the amino acid level, in H1 they differ with each other by 2 out of 290 positions. They differ with WSN/33 at 5 positions, but differ with the original WS/33 virus by 23 positions. Moreover, there are 60 differences with New Caledonia, the H1N1 human virus in today's vaccine. With 60 differences, those born after 1933 would have little immunity. The same situation is present in N1. There is only 1 amino acid differences between the two avian isolates (out of 364 positions) and 2 differences with WSN/33. Again there are 10 differences with WS/33 and 45 with New Caledonia (not counting the 16 amino acid deletion found in all except New Caledonia - all current human N1 isolates have the extra 16 amino acids). Similar situations are found for the other 5 human genes. Only PB2 is from birds (H9N2 found in Korea). The other H9N2 isolates from 2004 Korean pigs have H and N from the same Korean avian isolate and have 3-5 WSN/33 genes (and one is a recombinant in PB2 between WSN/33 and the H9N2 sequence found in the other swine isolates).

To: Jim McMannis who wrote (22585)	12/8/2004 2:38:49 PM
From: Henry Niman	Read Replies (1) \| Respond to of 110194

The story about 1933 human sequences in pigs in South Korea is attracting some attention. The samples were from pigs on a farm and can have some serious consequences recombinomics.com

To: Jim McMannis who wrote (22585)	12/10/2004 12:59:17 PM
From: Henry Niman	Respond to of 110194

Jim, I have done some more analysis of the 1933 sequences, and the data look very real recombinomics.com I believe this will pose a serious challenge.