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Biotech / Medical : Biotech Valuation -- Ignore unavailable to you. Want to Upgrade?

To: scaram(o)uche who wrote (14712)	12/17/2004 2:58:44 AM
From: Henry Niman	Read Replies (1) \| Respond to of 52153

In this instance the full sequence are publicly available at genbank. The two under the most discussion are H1N1 and are linked here recombinomics.com The number of WSN/33 sequences in their isolates is quite large (n=26), most are full sequences (many over 2200 nt each), and each isolate is different (but each human gene is over 99% homologous to WSN/33). The lab isolating the viruses has never knowingly had WSN/33, the MDCK cells in the lab are PCR negative for WSN/33, and the viruses were isolated in chicken eggs. The number of polymorphisms in the 26 published genes is quite large and they follow rules of influenza A evolution (and the viruses have genes that have reassorted and recombined with 2 or 3 H9N2 avain sequences). The sequence data is supported by serological data that is specific for the isolates with human genes (and the manuacript is under review at a very high level journal and being independently confirmed by at least two independent labs). In Vancouver the lab had some major contamination problems, had partial sequences which matched its positive control, and the SARS CoV sequences differed by a single nucleotide (and that polymorphisms had been found previously. Most paying attention would not consider the two situations comparable. If you have an explanation for the WSN/33 sequences in the pigs (or the submitted sequences), I would like to hear it (as would government agencies in Japan, South Korea, and WHO.