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Biotech / Medical : Biotech Valuation -- Ignore unavailable to you. Want to Upgrade?

To: Arthur Radley who wrote (16762)	5/12/2005 2:49:52 PM
From: tuck	Respond to of 52153

rNAPC2 has been around for some time. Believe Corvas started it, didn't get too far, got munched for peanuts by DNDN, which apparently managed to sell the thing to NUVO. That would make sense for DNDN, as rNAPC2 didn't address its core businesses. I think Corvas was munched for cash, and was chiefly opportunistic for DNDN, which, having outlicensed rNAPC2, apparently made a bit off the munch. >>Circulation. 2001 Jul 3;104(1):74-8. Dose-response study of recombinant factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement. Lee A, Agnelli G, Buller H, Ginsberg J, Heit J, Rote W, Vlasuk G, Costantini L, Julian J, Comp P, van Der Meer J, Piovella F, Raskob G, Gent M. Hamilton Civic Hospitals Research Centre, McMaster University, Hamilton, Ontario, Canada. BACKGROUND: With the best prophylactics now available, venous thromboembolism after total knee replacement remains substantial (25% to 27%). Recombinant nematode anticoagulant protein c2 (rNAPc2) is a potent inhibitor of factor VIIa/tissue factor complex that has the potential to reduce this risk. The present study was performed to determine an efficacious and safe dose of rNAPc2 for prevention of venous thromboembolism after elective, unilateral total knee replacement. METHODS AND RESULTS: This open-label, sequential dose-ranging study was conducted in 11 centers in Canada, Europe, and the United States. Five regimens were tested. Injections were administered subcutaneously on the day of surgery (day 1) and days 3, 5, and optionally, day 7. Primary efficacy outcome was a composite of overall deep vein thrombosis based on mandatory unilateral venography (day 7+/-2) and confirmed symptomatic venous thromboembolism recorded </=48 hours after the last dose of rNAPc2. Primary safety outcome was major bleeding </=72 hours after the last dose. An independent, blinded Central Adjudication Committee assessed all outcome events. Of 293 patients studied, 251 (86%) could be evaluated for primary efficacy analysis. A dosage of 3.0 microgram/kg administered within 1 hour after surgery provided the best observed results, with an overall deep vein thrombosis rate of 12.2%, a proximal deep vein thrombosis rate of 1.3%, and a major bleeding rate of 2.3%. CONCLUSIONS: A randomized, double-blind trial that compared rNAPc2 with current best prophylactics is warranted based on encouraging, first-reported clinical results for a factor VIIa/tissue factor inhibitor evaluated for thrombosis prophylaxis.<< ncbi.nlm.nih.gov Full text freebie. It also seemed to have promise in post exposure treatment of Ebola and other endotoxins, even showed antiangiogenic properties. DNDN inherited a PII DVT from Corvas, but had to drop it to focus on other indications. I think Miljenko used to follow Corvas, maybe others. Perhaps they can chime in about rNAPc2 odds here. Cheers, Tuck