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Biotech / Medical : Millennium Pharmaceuticals, Inc. (MLNM) -- Ignore unavailable to you. Want to Upgrade?

To: microcapfun who wrote (2442)	7/6/2005 12:19:16 AM
From: Icebrg	Read Replies (1) \| Respond to of 3044

MLN02 >> A typo???>> No. An excerpt from the original article in the NEJM. Human antihuman antibodies developed by week 8 in 44 percent of the patients who received MLN02. Overall, 24 percent of patients were positive for antibody at a titer of greater than 1:125. Corresponding values for the groups receiving 2.0 mg per kilogram and 0.5 mg per kilogram were 11 percent and 38 percent, respectively. In patients with this concentration of antibody, the rate of clinical remission was 12 percent, which was similar to the rate in the placebo group (14 percent). Furthermore, in patients with this concentration of antibody, {alpha}4{beta}7 binding sites on circulating CD4+CD45RO+ T lymphocytes became unsaturated. Conversely, in the 76 percent of patients who either tested negative or had lower titers of antibody, the clinical-remission rate was 42 percent and these binding sites remained saturated. content.nejm.org