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Biotech / Medical : DPII: Discovery Partners Int'l -- Ignore unavailable to you. Want to Upgrade?

To: Mike McFarland who wrote (17)	8/10/2005 9:47:32 PM
From: Mike McFarland	Read Replies (1) \| Respond to of 111

Misc stuff about their Kans: IRORI’s NanoKan system extends encoding to the use of machine readable barcodes and theoretically allows libraries of up to 10,000 members to be prepared bentham-science.org Temperature/Stability profile of IRORI Kans by Pui Yee Ng see page 20 biotagedcg.com "However, from the perspective of our research and training goals in chemical genetics, the IRORI system suffers from two shortcomings, both relating to cost. First, given our ability to perform highly miniaturized and effective phenotypic [5] and protein-binding assays [6,7], we calculate that an optimal sample size of compound derived from an individual bead (of which a Kan is a functional equivalent) is closer to 0.1 mg. Since the majority of compounds synthesized in a split-pool synthesis will not score as a positive in an assay, over- synthesis is costly and wasteful. Second, we aimed to develop a simple and inexpensive system, one, for example, that could be re-established by a trainee at a second site within the constraints of a typical academic budget. If chemical genetics is to have the broad applicability of biochemistry and genetics as a vehicle to explore biology, it must be portable, accessible, and costcontained. This is an issue that also faces genomics as it evolves into a broadly applicable means to explore biology." broad.mit.edu