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Politics : Rat's Nest - Chronicles of Collapse -- Ignore unavailable to you. Want to Upgrade?

To: Pogeu Mahone who wrote (1961)	8/28/2005 5:06:30 AM
From: Wharf Rat	Respond to of 24213

RBC’s main function is the distribution and removal of O2 and CO2 throughout the body. Each RBC contains hemoglobin which allows the carrying of O2 and CO2. Hemoglobin is composed of four polypeptide globin chains, which each contain a haem molecule. These polypeptide chains undergo conformational changes and move with respect to each other during the binding of O2 and CO2. 2, 3- diphosphoglycerate (2,3-DPG) binds between the ß1 and ß2 chains to reduce affinity for O2, in turn stabilizing deoxyhemoglobin. This allows the O2 to release into the tissue. Hemoglobin containing O2 is referred to Oxyhaemoglobin. Conditions that cause the quality of oxygen transported to decrease will cause the increased production of RBC’s from the bone marrow. Erythropoietin, a glycoprotein, is converted from a plasma protein into this hormone. Erythropoietin stimulates the production of erythrocytes in bone marrow through, erythropoiesis. At very high altitudes, the quantity of O2 is vastly decreased; therefore, RBC production is increased and people living at these altitudes will have a greater number of RBC’s. stclairdale.tripod.com

To: Pogeu Mahone who wrote (1961)	8/28/2005 5:30:18 AM
From: Wharf Rat	Respond to of 24213

In my bible, it sez... Erythropoietin, it's response to hypoxia, and its function in regulating red blood cell production Erythropoietin, also called erythropoietic stimulating factor, or hemopoietin, is a glycoprotein that has a molecular weight between 25K and 45K, and that is formed in the tissues of the body in response to hypoxia. EPO in turn acts on the bone marrow to increase the rate of rbc production. Especially large quantities of EPO are formed in the kidneys during hypoxia, but lesser amounts seem also to be formed in the liver and possibly even other tissues. There is no direct response of the marrow to hypoxia. Instead, hypoxia stimulates rbc production only thru the mechanism of EPO. Though EPO begins to be formed in the kidneys almost immediately upon placing an animal or person in an atmosphere of low O2, very few rbcs appear in the circulating blood volume within the first 2 days, and it is only after 3 or 4 days that the maximum rate of RBC production is reached. Upon removal of a person from a state of low O2, his rate of O2 transport to the tissues rises above normal,which causes the rate of EPO formation to decrease to zero almost instantaneously and his rate of rbc production to fall to essentially zero within 24-36 hours. Authur Guyton Textbook of Medical Physiology Pg 100 1971