SI
SI
discoversearch

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor.  We ask that you disable ad blocking while on Silicon Investor in the best interests of our community.  If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.
Biotech / Medical : Trickle Portfolio -- Ignore unavailable to you. Want to Upgrade?


To: tuck who wrote (1749)9/8/2005 4:36:36 PM
From: tuck  Respond to of 1784
 
UltraFast Electron Microscopy

>>Published online before print May 9, 2005, 10.1073/pnas.0502607102
PNAS | May 17, 2005 | vol. 102 | no. 20 | 7069-7073

CHEMISTRY / BIOPHYSICS
Four-dimensional ultrafast electron microscopy
Vladimir A. Lobastov, Ramesh Srinivasan and Ahmed H. Zewail *

Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125

Contributed by Ahmed H. Zewail, March 30, 2005

Electron microscopy is arguably the most powerful tool for spatial imaging of structures. As such, 2D and 3D microscopies provide static structures with subnanometer and increasingly with ångstrom-scale spatial resolution. Here we report the development of 4D ultrafast electron microscopy, whose capability imparts another dimension to imaging in general and to dynamics in particular. We demonstrate its versatility by recording images and diffraction patterns of crystalline and amorphous materials and images of biological cells. The electron packets, which were generated with femtosecond laser pulses, have a de Broglie wavelength of 0.0335 Å at 120 keV and have as low as one electron per pulse. With such few particles, doses of few electrons per square ångstrom, and ultrafast temporal duration, the long sought after but hitherto unrealized quest for ultrafast electron microscopy has been realized. Ultrafast electron microscopy should have an impact on all areas of microscopy, including biological imaging. <<

To get an idea of the impact of this stuff, see:

corante.com

Cheers, Tuck



To: tuck who wrote (1749)9/30/2005 9:56:46 AM
From: tuck  Read Replies (1) | Respond to of 1784
 
Third Wave nevertheless got a permanent injunction, but now is getting flak from another flank:

>>MADISON, Wis., Sept. 30 /PRNewswire-FirstCall/ -- Third Wave Technologies Inc. (Nasdaq: TWTI - News) today responded to a lawsuit filed against it by Innogenetics N.V., Gent, Belgium, that alleges Third Wave is infringing one of Innogenetics' hepatitis C virus (HCV) patents. Innogenetics also filed a similar suit against Abbott Laboratories. Both suits were filed in U.S. District Court for the Western District of Wisconsin in Madison, Wis.

"Third Wave is well versed in the HCV patent landscape and has taken great care to understand and respect all the major patents in the field, including those held by Innogenetics," said Kevin Conroy, vice president and general counsel of Third Wave. "Innogenetics' suit lacks a basic understanding of the uniqueness of Third Wave's Invader® chemistry and how it is configured in our HCV analyte-specific reagents. It appears that Innogenetics filed suit against Third Wave without first understanding how our product is designed. In addition to our belief that Third Wave is not infringing Innogenetics' patent, we believe the Innogenetics' patent is invalid."

Third Wave and Innogenetics are marketing partners in Europe and have been in discussions about the possible expansion of their distribution partnership.<<

snip

Cheers, Tuck (who is STILL on jury duty)



To: tuck who wrote (1749)10/13/2005 9:37:38 AM
From: tuck  Read Replies (1) | Respond to of 1784
 
Stratagene loses another legal round, tis time against Invitrogen:

>>CARLSBAD, Calif. (AP) -- Invitrogen Corp., a maker of genomics research equipment, said Thursday that an appeals court ruled in its favor in a patent infringement case brought against Stratagene Inc.

The appeal overturned a decision by a federal district court in Texas and ruled that Stratagene infringed a patent involving a process that allows bacteria to absorb foreign DNA, or become "competent."

Invitrogen said it offers 30 different types of competent cell products, which require obtaining a limited license for purchase. The company claimed that Stratagene never obtained a license for their competent cell products.

As a result, the case will go back to the district court level for continued proceedings.<<

Cheers, Tuck



To: tuck who wrote (1749)11/8/2005 4:48:08 PM
From: tuck  Respond to of 1784
 
Despite the spate of small legal losses, STGN won a big one, being a party in the CAT/Abbott litigation involving Humira; I wasn't aware they had a finger in that pie.

>>LA JOLLA, Calif.--(BUSINESS WIRE)--Nov. 8, 2005--Stratagene Corporation (Nasdaq:STGN - News), a developer, manufacturer and marketer of specialized life science research and diagnostic products, today released financial results for the third quarter ended September 30, 2005.

For the third quarter of 2005, revenue grew 3% to $23.7 million compared with $23.1 million in the third quarter of 2004. For the nine-month period ended September 30, 2005, revenue was $73.2 million, up 17.6% from the comparable period of 2004.

"Our third quarter revenue results were in-line with our expectations," said Joseph A. Sorge, MD, President and CEO of Stratagene Corporation. "Within our life sciences research business, we continued to make strong progress in sales of QPCR products, which grew 23% in the third quarter of 2005 compared with the same period of 2004 and 20% year-to-date. We believe our innovative instrument offering and our wide menu of unique reagent chemistry should allow us to sustain our double-digit growth rate for QPCR products into 2006.

"Our allergy clinical diagnostics product line achieved growth of 10% in the third quarter of 2005 and was the fastest growing diagnostics product line during the quarter and in the first nine months of 2005," continued Dr. Sorge. "This continued strength in our core business provides us with the financial flexibility to further develop our commercial molecular diagnostics product line."

For the third quarter of 2005, the Company generated net income of $0.7 million, or $0.03 per diluted share, compared with $2.2 million, or $0.10 per diluted share, in the comparable quarter of 2004. For the first nine months of 2005, the Company achieved net income of $5.8 million, or $0.26 per diluted share, compared with $5.7 million, or $0.31 per diluted share, during the comparable period of 2004.

Net income in the third quarter of 2005 and for the first nine months of 2005 was negatively impacted by approximately $2.5 million, or $0.07 per share, and $4.0 million, or $0.12 per share, respectively, for legal expenses primarily associated with two patent litigation matters when compared to the same periods of the prior year.

Prior year net income in the third quarter of 2004 was positively impacted by proceeds from a litigation settlement of approximately $665,000 which was partially offset by the effect of a 46% income tax rate due to the non-deductibility of start-up expenses in Japan. Together, these two items increased third quarter 2004 earnings per share by $0.01.

As previously announced, the matter of Third Wave Technologies versus Stratagene Corporation was tried before a jury in the United States District Court for the Western District of Wisconsin in August 2005. On August 31, 2005, the jury returned a verdict unfavorable to Stratagene and awarded Third Wave $5.29 million in damages. Subsequently, the judge in the matter issued an injunction barring sales of the infringing products, which have totaled approximately $400,000 since their inception in early 2004. Post-trial motions have been filed in the District Court and a final decision by the court is expected before the end of the year. Stratagene intends to file an appeal in the Court of Appeals for the Federal Circuit in Washington, D.C. after the Court rules on the post-trial motions and will seek to have the damages awarded by the court reduced or eliminated and the injunction lifted.

"We believe that it is imperative that we vigorously defend our patent position and protect the value of this asset on behalf of all of our stakeholders," said Dr. Sorge. "Fortunately, we believe our ability to enter the molecular diagnostics marketplace is unaffected by the court's decision, since we are free to utilize our non-infringing embodiments of the technology."

The Company is unable to determine the amount or timing of any final damage award that may be rendered upon the final outcome of this case and therefore has not recorded a liability accrual within the third quarter 2005 financial statements for this matter.

Stratagene has served Third Wave with the lawsuit that Stratagene filed on May 6, 2005 for infringement of Stratagene's patents covering its proprietary FullVelocity(TM) technology for the quantitative detection of nucleic acids. The suit was filed in the U.S. District Court for the District of Delaware and seeks monetary damages as well as a permanent injunction against continued infringement by Third Wave with respect to the sale of its Invader® Plus products.

As of September 30, 2005, cash, cash equivalents and marketable securities were approximately $9.0 million and total assets were $85.2 million. Since early 2004 through September 30, 2005, Stratagene has repaid approximately $17 million of debt. As of September 30, 2005, total debt was $4.0 million.

Stratagene was a privately held company until June 2, 2004, when it merged with Hycor Biomedical Inc. (formerly Nasdaq: HYBD) with Hycor surviving as a wholly owned subsidiary of Stratagene. Stratagene's 2005 results include the results of Stratagene combined with the results of Hycor. Stratagene's 2004 results include the results of Stratagene combined with the results of Hycor from the June 2, 2004 merger date through the end of 2004. The financial results include incremental Hycor revenues of $17.6 million in the first nine months of 2005 and $7.7 million in the first nine months of 2004.

Gross margin on product sales was 64.4% for the third quarter of 2005 compared with 65% for the same quarter of 2004. The decrease in gross margin was related to a greater mix of lower margin instruments sold in the third quarter of 2005.

Selling and marketing expenses increased 11.4% to $5.3 million in the third quarter compared with $4.8 million in the third quarter of last year, reflecting the cost of additional sales and marketing costs in Japan and increased personnel costs.

General and administrative expenses increased 58% in the third quarter to $5.9 million compared with $3.7 million in the third quarter of 2004. General and administrative expenses in the third quarter of 2005 were impacted by the higher legal expenses described above.

One-Time Cash Dividend Announced

Stratagene also announced today a special one-time cash dividend of $0.25 per common share payable on January 6, 2006 to stockholders of record as of December 16, 2005. The Company's board of directors, after considering the Company's anticipated liquidity needs, unanimously authorized the special dividend as a result of the Company's recognition of approximately $14.6 million in after-tax income in the fourth quarter of 2005 related to a settlement. The settlement, which was announced on October 26, 2005, relates to the licensing of certain Stratagene technology to Cambridge Antibody Technology and the subsequent use of this technology in the commercialization of Abbott's Humira® product.

Outlook

The fourth quarter 2005 financial results will include the positive impact to Stratagene of the favorable settlement announced on October 26, 2005 between Abbott Laboratories, Cambridge Antibody Technology, Stratagene and other patent owners related to sales of Abbott's Humira® product for the treatment of rheumatoid arthritis.

Stratagene and the patent owners agreed to a lump sum payment plus a lesser future contingent payment to satisfy their interest with respect to the Humira® collaboration. Stratagene expects to recognize approximately $23.6 million in pretax income from this settlement in the fourth quarter of 2005. The net income effect is expected to be approximately $14.6 million after taxes or $0.66 per share.

Excluding the impact of the settlement income, the Company is refining its revenue guidance for the full year to $96 to $98 million.

The Company is adjusting its full year earnings per share guidance to reflect the continued impact from legal costs associated with two patent litigation matters, as well as the Abbott - Cambridge Antibody Technology settlement. Such guidance does not reflect any possible effect of any damages or other award in the two patent litigations. Accordingly, the Company is adjusting its previously announced guidance range from $0.33 to $0.37 per share to $0.96 to $0.99 per share for the full year 2005.

Conference Call Today

Stratagene will host a conference call and webcast today, Tuesday, November 8, 2005, at 4:30 p.m. Eastern Time to discuss the Company's third quarter 2005 results, outlook for the remainder of 2005, as well as current corporate developments. The dial-in number for the conference call is 800-240-2430 for domestic participants and 303-262-2143 for international participants.

A taped replay of the conference call will also be available beginning approximately one hour after the call's conclusion and will remain available for seven days. It can be accessed by dialing 800-405-2236 for domestic callers and 303-590-3000 for international callers, using the passcode 11041716#. To access the live webcast of the call, go to Stratagene's website at stratagene.com and click on the Investors icon. An archived webcast will also be available at stratagene.com. <<

snip

Cheers, Tuck