To: donpat who wrote (571 ) 10/11/2005 6:23:39 AM From: Walkingshadow Read Replies (2) | Respond to of 1694 You gotta be joking. Targeting something like HIV is almost unimaginably difficult. It is not nearly as easy as that two-bit website would have you believe. And that's why a small army of some of the best minds in the world have used up billions in research funds over a quarter century and have only managed to come up with treatments that slow the progression of the disease or are palliative. That's certainly not for lack of effort or lack of ability. Do you really imagine that a couple of nobodys can do better? Seymour and Diwan between them have a grand total of 5 "publications" on HIV. Seymour's last was 12 years ago, none were peer reviewed or original, and in fact two were just letters to the editor expressing an opinion. Diwan has two inconsequential papers on HIV, one a case report, and another a lab study in 1998 published in junk-mail journal. These jokers are experts?? On what, pray tell?? Better yet, don't tell me. I don't think I even want to know. By contrast, between them, Robert Gallo and Luc Montagnier have published well over 1000 papers, many in the best journals in the world, with the highest standards. So.... NNVC wants to have a picnic, eh? Well well well.... how about a nice little torrential rainstorm??? Problem #1: How do you find HIV? The vast majority of them are intracellular the vast majority of the time, are often not in "particle" form at all, but instead integrated right into the genome, hiding among trillions of very similar nucleotide sequences. Imagine not a needle in a haystack, but a needle in a mountain of hay. Stupid NNVC antibodies or ligands have zero hope, partly because antibodies can't get into cells, and partly because even if they could, they couldn't get into the nucleus, and IF by some magic they COULD get into the nucleus, they wouldn't know where to begin, because antibodies mostly target proteins, not nucleic acids, much less nucleic acid compacted around histones like the string inside a softball and that is indistinguishable from all the other DNA that's supposed to be there. So antibodies or other ligands couldn't begin to find HIV that had become integrated into the genome. Okay, but just for kicks, let's assume the antibodies work against viral proteins. Still, no good. Because IF they recognize viral proteins, they'll only work on assembled virus particles that just happen to be roaming around the blood stream. And HIV is smart enough to avoid taking a stroll in the blood stream in broad daylight most of the time. And IF the antibodies work for that very limited set of virions, they won't likely work for long, given that coat proteins are notoriously hypervariable. Okay. And that's just problem #1. There's lots more problems, just in case any are needed. Problem #2: Do you realize how fast HIV can replicate? How do you keep up? Got trillions of antibodies? Good. You're gonna need it. And then some. Constantly. Problem #3: At least 1 or 2 billion new cells are infected every day in each HIV patient. And many of these cells will live for weeks, busily making more virus very quickly, exponentially in fact. And releasing them to infect other cells. This is a problem similar to trying to track down and destroy every bot out there amongst the army of bots constantly in motion sending out trillions of spam e mails every second of every day. Losta luck. Problem #4: HIV is very good at accumulating in privileged reservoirs where they basically are safe. There are reservoirs where HIV can thrive for many years, and this is common. Problem #5: Trojan horse strategies are a neat idea for cells, but generally useless for viruses, and even if they were useful, they are usually not necessary. Viruses are not very hard to kill. Killing virus particles is not the problem. The only thing that NNVC's "technology" can possibly accomplish is to enrich the company officers and their henchmen and shills by selling paper to millions of investors who don't know any better. And, sadly, no doubt fortunes will be made (and lost) in the process until they finally vanish in a cloud of smoke. Happens every day. T