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To: LJM who wrote (4244)10/22/2005 8:20:08 PM
From: Shawn Donahue  Read Replies (1) | Respond to of 7143
 
Parrot in British quarantine dies of bird flu - but strain may not be deadly for humans
By James Burleigh
Published: 22 October 2005

A parrot which died in quarantine in the UK has tested positive for avian flu, the Department for Environment Food and Rural Affairs confirmed last night.

The bird, which was imported from South America and arrived in this country in mid-September, was found to contain the H5 strain of the virus after scientists carried out tests following its death a couple of days ago.

It is the first time a case of avian flu has been confirmed in Britain since 1992 but Defra were unable to confirm if it is the lethal strain H5N1, which has killed 60 people in south-east Asia.

The chief veterinary officer, Debby Reynolds, said last night: "We do know it is a highly pathogenic form, but we don't have the formal, official confirmation of the N-type. I don't intend to speculate on the N-type until I have formal, official confirmation of this."

The bird was part of a mixed consignment of 148 parrots and "soft bills" which arrived on 16 Sept-ember from Surinam and were being held in a biosecure quarantine unit with a consignment of around 200 birds from Taiwan. The birds - around 300 in total - have now all been humanely culled and all those which came in contact with the culled consignment have been given antiviral treatment, Defra said.

Asked about the incidence of avian flu in Surinam, she added: "I am not aware of any official reports, but that is something we need to absolutely check."

The confirmed case did not affect the UK's official disease-free status because the disease was identified in imported birds during quarantine, according to Ms Reynolds, and this was later confirmed by European Union officials. Ms Reynolds said this incident "showed the importance of the UK's quarantine system".

Professor Hugh Pennington, of Aberdeen University's department of medical microbiology, said tests would have to be carried out on the dead parrot to establish whether it died from the strain of H5N1 which has killed birds across the Far East and Europe.

He said that, as well as different, less dangerous strains of the virus, it was possible the bird died of another H5-type virus, as it had come from South America where the Far East avian flu has not been found.

Avian flu has been found in Romania, Turkey and Greece in recent weeks after apparently being carried by wild birds from Asia. Last night it was also confirmed in Croatia.

Earlier today the EU ordered restrictions on bird markets and shows and urged nations to present a programme of vaccination for zoo birds as part of increased measures to avert the spread of bird flu.

The European Commission announced it was considering setting aside a €1bn (£677m) "solidarity fund" to be used in the event of a pandemic. Money would be used for anti-viral drugs and vaccines to help combat a potentially deadly outbreak.

Earlier this week Patricia Hewitt, the Health Secretary, said the UK had already ordered a large quantity of the anti-viral drug Tamiflu to treat flu victims, as well as a smaller quantity of vaccine against the current strain of bird flu.

She also said the risk of a pandemic remains unchanged, according to the World Health Organisation. "There is no evidence of avian flu being transmitted from one person to another - human-to-human transmission, that is what would be required for a pandemic," she said.

Avian flu is a highly infectious viral disease which affects birds and varies in severity, from causing no deaths to killing entire flocks within hours. Warning signs include breathing problems, swollen heads and a drop in egg production. It is most easily spread through bird secretions, particularly faeces, but can also be passed via contaminated objects.

The deadliest strain of the virus is H5N1. It is also highly contagious and so has sparked global concern. It kills almost all infected fowl, many within 24 hours. The strain has leapt the species barrier, killing 60 people working with stricken birds in south-east Asia. The fear is H5N1 will mutate so it becomes more easily transferable from human to human.

A virus in many forms

* There are many strains of Avian Influenza (AI) which vary in their ability to cause disease.

* The different types of AI viruses are categorised according to their ability to cause severe disease (pathogenicity) as either highly pathogenic avian influenza (HPAI) viruses or low pathogenic (LPAI).

* One of the most dangerous is the strain that is identified as H5N1.

* The most contagious strains are H5 and H7 and both of those are usually fatal to birds.

* The H5 part of the strain can be identified more easily than the N-number.

* It has been established that the dead parrot has the H5 strain but the N-number, which may determine whether it will kill humans, is unknown. Further tests are required to answer this question

* Testing for suspected cases in Europe is carried out by scientists at a specialist laboratory in Weybridge, Surrey.

A parrot which died in quarantine in the UK has tested positive for avian flu, the Department for Environment Food and Rural Affairs confirmed last night.

The bird, which was imported from South America and arrived in this country in mid-September, was found to contain the H5 strain of the virus after scientists carried out tests following its death a couple of days ago.

It is the first time a case of avian flu has been confirmed in Britain since 1992 but Defra were unable to confirm if it is the lethal strain H5N1, which has killed 60 people in south-east Asia.

The chief veterinary officer, Debby Reynolds, said last night: "We do know it is a highly pathogenic form, but we don't have the formal, official confirmation of the N-type. I don't intend to speculate on the N-type until I have formal, official confirmation of this."

The bird was part of a mixed consignment of 148 parrots and "soft bills" which arrived on 16 Sept-ember from Surinam and were being held in a biosecure quarantine unit with a consignment of around 200 birds from Taiwan. The birds - around 300 in total - have now all been humanely culled and all those which came in contact with the culled consignment have been given antiviral treatment, Defra said.

Asked about the incidence of avian flu in Surinam, she added: "I am not aware of any official reports, but that is something we need to absolutely check."

The confirmed case did not affect the UK's official disease-free status because the disease was identified in imported birds during quarantine, according to Ms Reynolds, and this was later confirmed by European Union officials. Ms Reynolds said this incident "showed the importance of the UK's quarantine system".

Professor Hugh Pennington, of Aberdeen University's department of medical microbiology, said tests would have to be carried out on the dead parrot to establish whether it died from the strain of H5N1 which has killed birds across the Far East and Europe.

He said that, as well as different, less dangerous strains of the virus, it was possible the bird died of another H5-type virus, as it had come from South America where the Far East avian flu has not been found.

Avian flu has been found in Romania, Turkey and Greece in recent weeks after apparently being carried by wild birds from Asia. Last night it was also confirmed in Croatia.

Earlier today the EU ordered restrictions on bird markets and shows and urged nations to present a programme of vaccination for zoo birds as part of increased measures to avert the spread of bird flu.
The European Commission announced it was considering setting aside a €1bn (£677m) "solidarity fund" to be used in the event of a pandemic. Money would be used for anti-viral drugs and vaccines to help combat a potentially deadly outbreak.

Earlier this week Patricia Hewitt, the Health Secretary, said the UK had already ordered a large quantity of the anti-viral drug Tamiflu to treat flu victims, as well as a smaller quantity of vaccine against the current strain of bird flu.

She also said the risk of a pandemic remains unchanged, according to the World Health Organisation. "There is no evidence of avian flu being transmitted from one person to another - human-to-human transmission, that is what would be required for a pandemic," she said.

Avian flu is a highly infectious viral disease which affects birds and varies in severity, from causing no deaths to killing entire flocks within hours. Warning signs include breathing problems, swollen heads and a drop in egg production. It is most easily spread through bird secretions, particularly faeces, but can also be passed via contaminated objects.

The deadliest strain of the virus is H5N1. It is also highly contagious and so has sparked global concern. It kills almost all infected fowl, many within 24 hours. The strain has leapt the species barrier, killing 60 people working with stricken birds in south-east Asia. The fear is H5N1 will mutate so it becomes more easily transferable from human to human.

A virus in many forms

* There are many strains of Avian Influenza (AI) which vary in their ability to cause disease.

* The different types of AI viruses are categorised according to their ability to cause severe disease (pathogenicity) as either highly pathogenic avian influenza (HPAI) viruses or low pathogenic (LPAI).

* One of the most dangerous is the strain that is identified as H5N1.

* The most contagious strains are H5 and H7 and both of those are usually fatal to birds.

* The H5 part of the strain can be identified more easily than the N-number.

* It has been established that the dead parrot has the H5 strain but the N-number, which may determine whether it will kill humans, is unknown. Further tests are required to answer this question

* Testing for suspected cases in Europe is carried out by scientists at a specialist laboratory in Weybridge, Surrey.
news.independent.co.uk



To: LJM who wrote (4244)11/1/2005 2:46:20 PM
From: Shawn Donahue  Read Replies (2) | Respond to of 7143
 
Bush Outlines $7.1B Flu-Fighting Strategy By LAURAN NEERGAARD, AP Medical Writer
1 hour, 52 minutes ago


WASHINGTON - President Bush outlined a $7.1 billion strategy Tuesday to prepare for the danger of a pandemic influenza outbreak, saying he wanted to stockpile enough vaccine to protect 20 million Americans against the current strain of bird flu as a first wave of protection.


The president also said the United States must approve liability protection for the makers of lifesaving vaccines. He said the number of American vaccine manufacturers has plummeted because the industry has been hit with a flood of lawsuits.

Bush said no one knows when or where a deadly strain of flu will strike but "at some point we are likely to face another pandemic."

The president, in a speech at the National Institutes of Health, said the United States must be prepared to detect outbreaks anywhere in the world, stockpile vaccines and anti-viral drugs and be ready to respond at the federal, state and local levels in the event a pandemic reaches the United States.

Bush outlined a strategy that would cost $7.1 billion including:

_$1.2 billion for the government to buy enough doses of the vaccine against the current strain of bird flu to protect 20 million Americans; the administration wants to have sufficient vaccine for front-line emergency personnel and at-risk populations, including military personnel;

_$1 billion to stockpile more anti-viral drugs that lessen the severity of the flu symptoms;

_$2.8 billion to speed the development of vaccines as new strains emerge, a process that now takes months. The goal is to have the manufacturing capability by 2010 to brew enough vaccine for every American within six months' of a pandemic's start.

_$583 million for states and local governments to prepare emergency plans to respond to an outbreak.

Bush said a pandemic flu would be far more serious than the seasonal flu that makes hundreds of thousands of people sick ever year and sends people to their doctors for a flu shot. "I had mine," Bush said. Unlike seasonal flu, pandemic flu can kill people who are young and healthy as well as those who are frail and sick, he said.

In asking Congress for money to buy vaccine, Bush said the vaccine "would not be a perfect match to the pandemic flu because the pandemic strain would probably differ somewhat from the avian flu virus it grew from. But a vaccine against the current avian flu virus would likely offer some protection against a pandemic strain and possibly save many lives in the first critical months of an outbreak."

He also said the United States was increasing stockpiles of antiviral drugs, such as Tamiflu and Relenza. Such drugs cannot prevent people from catching the flu, but they can reduce the severity of the illness when taken within 48 hours of getting sick, he said.

"At this moment there is no pandemic influenza in the United States or the world, but if history is our guide there's reason to be concerned," Bush said. "In the last century, our country and the world have been hit by three influenza pandemics, and viruses from birds contributed to all of them."

He pointed out that the 1918 pandemic killed over a half million Americans and more than 20 million people across the globe. "One-third of the U.S. population was infected, and life expectancy in our country was reduced by 13 years.

"The 1918 pandemic was followed by pandemics in 1957 and 1968, which killed tens of thousands of Americans and millions across the world," Bush said.

Bird flu has been documented in Asia and has spread to Europe but has not reached the United States, the president said. "Our country has been given fair warning of this danger to our homeland and time to prepare," he said.

Bush said the cornerstone of his strategy was to develop new technologies to produce new vaccines quickly. "If a pandemic strikes, our country must have a surge capacity in place that will allow us to bring a new vaccine online quickly and manufacture enough to immunize every American against the pandemic strain," Bush said.

The principal goal of Bush's plan, Health and Human Services Secretary Michael Leavitt said, "is the capacity for every American to have a vaccine in the case of a pandemic, no matter what the virus is."

"There is no reason to believe that in the next day or two or week or month that that's going to occur," Leavitt said on CBS's "The Early Show." But he added that "we do need to be ready in case it begins to mutate into a human transmissible disease."

Pandemics strike when the easy-to-mutate influenza virus shifts to a strain that people have never experienced before, something that has happened three times in the last century. While it is impossible to say when the next super-flu will strike, concern is growing that the bird flu strain known as H5N1 could trigger one if it mutates to start spreading easily among people. Since 2003, at least 62 people in Southeast Asia have died from H5N1; most regularly handled poultry.

The nation's strategy starts with attempting to spot an outbreak abroad early and working to contain it before it reaches the United States.

Today, most of the world's vaccine against regular winter flu, including much of that used by Americans each flu season, is manufactured in factories in Britain and Europe.

The government already has ordered $162.5 million worth of vaccine to be made and stockpiled against the Asian bird flu, more than half to be made in a U.S. factory.

But the administration plan, to be released in more detail on Wednesday, calls for more than stockpiling shots. It will stress a new method of manufacturing flu vaccines — growing the virus to make them in easy-to-handle cell cultures instead of today's cumbersome process that uses millions of chicken eggs — as well as incentives for new U.S.-based vaccine factories to open.

___

Associated Press Writer Nedra Pickler contributed to this report.
news.yahoo.com