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Biotech / Medical : Sepracor-Looks very promising -- Ignore unavailable to you. Want to Upgrade?

To: scaram(o)uche who wrote (9165)	1/9/2006 11:44:22 PM
From: rkrw	Read Replies (1) \| Respond to of 10280

Is trazodone a tricyclic? It's probably the most rx'd drug for sleep.

To: scaram(o)uche who wrote (9165)	1/9/2006 11:50:59 PM
From: Biomaven	Read Replies (1) \| Respond to of 10280

Human : Not exactly known, clinical experience indicates a rather high acute toxicity, as is the case with other tri-/tetracyclics. Fatal dose in sensitive adults may be as low as 500 to 1,000mg oral (7 to 14mg/kg). In children below 12 yrs. of age any oral intake is to be considered as serious. So likely would need in excess of 100 6mg pills. But I guess if you added some other CNS depressants like alcohol the fatal dose would be much lower (but the same might go for Lunesta, although Zopiclone is very safe by itself, with someone reportedly recovering from more than 50x the normal dose). It's a lot harder to suicide with modern-day sleeping pills. Some benzo's and stuff like chloral hydrate (which incredibly is apparently still used in the UK) are a different story altogether. Peter