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To: SiteTracker who wrote (14056)3/24/2006 11:06:55 AM
From: russet  Read Replies (1) | Respond to of 14101
 
An amazing post. Obviously not one from a card carrying cult member.

Adding to one point a bit,...DMX never proved the mechanism of action of the DMSO carrier was the microtubule transport model. Alternative mechanisms that explain the clinical data are possible, and could lead the FDA to demand longer term studies. If DMSO disrupted normal cell waste removal mechanisms (exocytosis, membrane protein based removal pumps etc.) thereby favoring diffusion of Diclofenac from cell to cell via normal cell to cell membrane portals, there should be concern that other normal cell activities could be disrupted. The FDA was right to request longer term chronic pain studies especially in older subjects.



To: SiteTracker who wrote (14056)5/3/2006 6:17:48 PM
From: Mark Bartlett  Respond to of 14101
 
Excellent post -- one of the best I have read on any site.

I guess we shall see what unfolds over the next few months.

- Mark