To: koan who wrote (11708 ) 5/21/2006 4:04:28 PM From: E. Charters Read Replies (1) | Respond to of 78420 rense.com XThe history of vitamin E, its early massive rejection for about 40 years and its increasing acceptance today is very interesting and contains many lessons for physicians and for medical schools. The only reason it was so thoroughly rejected is that physicians knew hardly anything about vitamins. For decades, vitamin E pioneers Drs. Wilfred and Evan Shute were deprived of any recognition which was deservedly theirs. At the end of their lives they had some satisfaction from the recognition they received from orthomolecular physicians. They were the first doctors who had to face the unreasonable and unrelenting opposition of the medical establishment for their espousal of megadoses of a vitamin. This opposition was totally unscientific. The trick was that the Shutes used a natural substance, wheat germ oil, and extracted their vitamin E from it. This produced a mixed group of tocopherols and tocotrienols, the efficacy of which has never otherwise been studied properly. It is a very complex matter. The subsequent investigators used DL-alphatocopherol which is a synethic. By a test on rat embryos it is fairly well established that DL-E has half the efficacy of d-alpha-tocopherol or non synthetic E, in mitigation of spontaneous embryonic abortion of fetuses. The nature of this test raise fair questions of it giving any sense to the manifold other dimensions of E's operation within the human body. In other words what other shortfalls may synthetic or DL-E have in its needed functions in humans? There is no way of knowing, but I feel it may fairly surmised that you cannot make sweeping assertions about the efficacy of the Shute's normal dosage recommendation of 800 to 1600 IU's of extracted E from WG oil, when trying to duplicate the work with perhaps 25 to 400 IU's of a synthetic substance that in one test on animals had half the potency. In order to duplicate or refute the Shute's work one would have to duplicate the substance, the clinical conditions, time frames and the methodology, double blind and with fair subjective and objective markers. The Shutes tested 50,000 patients over 50 years. They had the results they had with few complaints or clinical failures. To dimiss this record with improper testing or prejudice is tantamount to scientific incompetence of incalculable magnitude. Stope Rats (Studies show miners can benefit from Vitamin E as it protects from Air Pollution.) EC<:-}