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Biotech / Medical : Mining Cholesterol -- Ignore unavailable to you. Want to Upgrade?

To: loantech who wrote (16)	5/23/2006 11:39:46 PM
From: E. Charters	Read Replies (1) \| Respond to of 356

It is apparently not a given that one can use statins and niacin -AND- high levels of anti-oxidants. (aside -->strangely NO which is an oxide is also an anti-oxidant, so L-Arginine which promotes NO is a promoter of anti-oxidation). It is NOT recommended that users of niacin and statins take anti-oxidants such as E, C and Selenium in any major quantities. The reason for this is that the cholesterol reduction activity of the combined drugs is interfered with by anti-oxidants. (I don't know about Niacin alone, or the Statins alone, the research is for the combination.) I think that the jury may be out on the above. Whilst the serum levels of cholesterol with anti-oixidants may be higher, it says nothing about the size of HDL, the amount of HDL, its ratio to homocysteine and LDL, the degree of oxidation of cholesterol -OR- its tendency to plaque out on the arteries. After all, these are the all important but much harder to measure markers. As Linus Pauling pointed out with this experiments in vitaminology and heart health, when one first starts taking mega doses of vitamin C, the cholesterol in serum actually rises for a while. It takes time to stabilize and then it falls. Most of these tests use inadequate markers to really research anything as complex as cholesterol action in the body. It is interesting to note that the B vitamins, long disparaged by researchers as having no effect on heart health, are supposed by biochemists as indispensable in the metabolic processing of protein and fat. It is also true that cholesterol itself has a main feature of being used to promote metabolism of fat and maintenance of digestive processes. Could it be that the researchers vision is too narrow? If the B's are making the fat processing efficient they are aiding cholesterol in one of its main functions, and if that is true they would have to be keeping it from peroxidation, as it cannot function in that state. I have megadosed with B vitamins with one aim in mind. To clean my arteries and lose weight by increasing the efficiency of my metabolic processes. I lost 66 lbs in 6 months. Perhaps that does not prove the model but at least it does not dispute it. EC<:-}

To: loantech who wrote (16)	5/23/2006 11:50:36 PM
From: E. Charters	Respond to of 356

I think the article about "HDL hyperesponder", in other words people who become very high in HDL (a good thing) is from taking niacin alone. However it is OK in many medical practices to take niacin and a statin. Statins tolerate many other cholesterol reducing medications, which can be used in concert including I believe, Pantethine, Policonsanol, Guggulipid, and Inositol Hexanicotinate. Policosonal should perhaps not be used if on blood thinning medications. Seek medical advice on this topic. Guggul is a bile seqesterant. Check with your physician if interested in taking these with prescription statins. In many ways Guggul may imitate statins in its effects. It is approved for hypercholesterolemia treatment by the Indian Medical Association, and may be the world's oldest effective heart and circulatory medication with a history of 4000 years of use. Niacin is often prescribed with Clofibrate or Gemfibrozil EC<:-}