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Biotech / Medical : Biotech Valuation -- Ignore unavailable to you. Want to Upgrade?

To: former_pgs who wrote (20477)	7/11/2006 4:12:22 PM
From: Biomaven	Respond to of 52153

To offer the same level of efficacy, RSD's recurrence rate in a given period of time has to be 10% or lower! I would assume that if RSD doesn't work, then they proceed to cardioversion. So not clear that relative recurrence rate is that critical. Your point about doctors in the field is very significant. One driver here may simply be profitability and convenience. (No idea which way they cut). That might easily trump issues of efficacy. Peter

To: former_pgs who wrote (20477)	7/11/2006 4:20:21 PM
From: dr.praveen	Read Replies (1) \| Respond to of 52153

The efficacy of external cardioversion varies from 60-90%. As peter pointed out my point is they might use RSD 1235 before going to cardioversion. The main value driver of CRME is oral RSD1235. Complications of cardioversion: Complications may affect patients or health care workers. Injury incidence is 1 case per 1700 shocks for paramedics in the field. The patient may become hypoxic or hypoventilate from sedation. Most burns from shocks are superficial partial-thickness burns, but a few are deep. Cardiac complications include dysrhythmia, hypotension, and pulmonary edema. Inducible arrhythmias include bradycardia, atrioventricular (AV) block, asystole, VT, and VF. In patients with acute coronary syndromes or acute myocardial infarction, bradycardia or AV blocks can be induced, and they may need an external or internal pacemaker. VT and VF commonly occur in patients with prior similar history. Postcardioversion VF consists of 2 types. The first type occurs immediately after a shock and is related to improper synchronization. This type of VF readily responds to defibrillation (unsynchronized countershock). The second type is related to digitalis toxicity and manifests within a few minutes of cardioversion. Initially, it can be a junctional or paroxysmal atrial tachycardia, then VF, which can be difficult to convert to a sinus rhythm.