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Biotech / Medical : Infinity Pharmaceuticals -- Ignore unavailable to you. Want to Upgrade?

To: Mike McFarland who wrote (61)	8/3/2006 11:25:59 AM
From: Mike McFarland	Respond to of 210

presentation made yesterday yahoo.brand.edgar-online.com >Hsp90: Potential Universal Salvage Therapy >IPI-609 should be in the clinic in 2007 (file IND late this year) >$90M cash, should last 12-24 months (I say it would be nice if, perhaps with some Novartis milestones, that no new financings are needed until 504 is well through some phase II testing--perhaps no shareholder dilution til 2009?) >The vote is scheduled for September 12th >INFI trades Wednesday September 13th (well, I am voting yes, I don't suppose my .01% of the outstanding shares are going to swing it one way or the other ha ha) I'll try to keep my cheerleading down to a dull roar on this for the next couple years, and keep the flakier stuff when the shares inevitibly sag over on my TOL thread. I don't want to drive off Dr. Praveen and any newcomers;-)

To: Mike McFarland who wrote (61)	8/3/2006 12:49:43 PM
From: dr.praveen	Read Replies (1) \| Respond to of 210

Hi Mike, Astex is one of the Bio's on the top of my private bio's list :-) I want it to make it to the ipo so bad :-) For more info here it is: today.reuters.com I am also voting yes for the Infi merger...Best...Praveen

To: Mike McFarland who wrote (61)	8/30/2006 3:20:03 PM
From: nigel bates	Read Replies (2) \| Respond to of 210

>>Vernalis plc vernalis.com the real thing, there's probably a thread and I just never stumbled onto it<< Don't think so, but it will be interesting to see if we hear anything about the Novartis/Vernalis compound this year, since Novartis bought Neutec - In December 2003, Vernalis formed a research collaboration with the Novartis Institutes for BioMedical Research, Inc., (Novartis) to investigate inhibitors of Hsp90. After an initial six-month evaluation period, Novartis exercised its option to license exclusive worldwide rights to Vernalis’ Hsp90 programme. The companies are conducting a joint research programme under which Novartis provides research funding to Vernalis for an initial three-year period. In addition, Novartis is responsible for funding and conducting the development of product candidates as well as for commercialisation. In December 2005, Vernalis announced that Novartis had selected a preclinical development candidate and compound is expected to enter clinical development in H2 2006... Particularly since Novartis bought Neutec. I was intrigued by this line in the Novartis/Vernalis article you cited - Does Hsp70 limit the anticancer potential of Hsp90 inhibitors? Hsp70 is induced in response to Hsp90 inhibition by small molecules in almost all of the cell lines tested... Does that imply they didn't test/have any results for the Neutec 'grab' (antibody) ?