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Biotech / Medical : Cardiome -- CRME -- Ignore unavailable to you. Want to Upgrade?

To: dr.praveen who wrote (51)8/15/2006 7:56:05 PM
From: dr.praveen  Read Replies (1) | Respond to of 285
 
From one of my old posts on Cardiome

The mechanism of action of RSD1235 as I have understood is it is mild frequency and voltage dependent.

It blocks open channel Ina and early activating,voltage gated k channel(blocks I kur and I to) and also blocks I kach channels.

Other effects of RSD1235:

It has a rate enhanced activity on conduction
It has an atrial selective apd/erp prolongation
It has no effect on ventricular repolarisation
It has no adverse hemodynamic effects

It is less of a sodium channel blocker of the atrium, k channel blocker more, coz we would have seen more effect on the ventricle conduction velocity and action potential alteration and it would also effect qrs complex.

Regards,
Praveen



To: dr.praveen who wrote (51)8/16/2006 7:19:30 AM
From: kenhott  Respond to of 285
 
holy heck, 3 hrs. Better take my adhd pill.



To: dr.praveen who wrote (51)8/18/2006 11:18:14 AM
From: kenhott  Respond to of 285
 
Thanks for the link. Lucky I had seen most of the slides before and was able to fast forward to the Q&A section. A gone but not forgotten friend my mine worked with Camm when they were both at St. Bartholomew's.


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