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Biotech / Medical : Mining Cholesterol -- Ignore unavailable to you. Want to Upgrade?

To: Mark_H who wrote (161)	9/7/2006 12:47:04 AM
From: E. Charters	Respond to of 356

Take lots of L-arginine, L-Lysine, folic, pro-anthocyandins and B vitamins to counteract the effect of any sat fat you may consume. Consume only cold pressed organic oils, and sparingly. About 3 tblspns per day max. The main strategy in supplementation should be to DEOXIDIZE cholesterol, no so much as to reduced it. EC<:-}

To: Mark_H who wrote (161)	9/7/2006 12:59:30 AM
From: E. Charters	Respond to of 356

"Coconut oil feeding (of rats) produced significantly lower levels (p=<0.05) of pre-beta lipoproteins (VLDL) and significantly higher (p=<0.01) alpha-lipoproteins (HDL) relative to sunflower oil feeding."[4] This is contradictory with their assertion of harm. If in fact coconut oil leads to lower LDL and higher HDL, then it is beneficial in comparison to sunflower oil. I think one would need to ask the researchers to re-examine their data. The later assertions are not in line with the above obersvation. It is important to understand that rats metabolize fats completely different than humans and findings about cholesterol with respect to rats may be totally invalid in humans.

To: Mark_H who wrote (161)	9/8/2006 2:24:41 AM
From: E. Charters	Respond to of 356

Also, I have been unreserved in the past about lysine, thinking that the Pauling-Rath formula was unerring. What this may be tempered by is the fact that true intake of both arginine and lysine in meat and vegetables is widely varying, and to most people, unknown. What seems to be a consensus amongst researchers in recent years is that lysine in excess may in fact be harmful to the circulatory system. To that end it appears that arginine should be in excess of lysine in the diet, and contrary to Pauling, excess lysine may be harmful. Lysine is in excess in meats, and arginine should be more predominant in vegetables. Could this be in part why vegetarians have lower incidence of CVD than heavy meat eaters? It would seem that this whole ratio concept bears more investigation. For now I am averring that arginine supplementation should exceed lysine, and total lysine supplementation should not exceed 500 mgs. Total needs may not exceed 35 mgs per kg. However before one goes out to supplement to the recommended RDA.., bear in mind that Lysine is amply represented in most proteins, so it may be supplied in sufficient quantities already. So in fact is arginine. So the question arises, if these elements are first of all non-essential, i.e. made by the body, AND they are infood, why take them at all? the answer lies in the demonstrated therapeutic value of loading with these aminos and this information has been available for over a decade. There are also some cases where arginine should not be taken in great quantities. It would pay to do your own research with applicable texts. EC<:-}

To: Mark_H who wrote (161)	9/8/2006 3:40:21 AM
From: E. Charters	Read Replies (1) \| Respond to of 356

Arginine and its metabolites are known to cause plaque not to form on the endothelium, and also to cause disaggregation of platelets. (All good) Its effect on reduction of cholesterol is slight, if at all. As possible roles in reduction of plaque, L-arginine may interfere with cholesterol oxidation, or it may cause cholesterol to form larger globules. Still another mechanism may be that it helps lecithin emulsify LDL. This is just off the wall theory, as the main known activity of L-argine is to expand arteries, and the peripheral vascular system by promoting NOx formation. It is interesting to note that the beneficial effect of chronic usage of soy is now thought to be from its NOx promotion. All this against a backdrop of some studies showing a deleterious effect on recent heart attack patients from supplementing with arginine. Really sick people should be careful about drastic supplementation. Frankly I would not supplement arginine at all in a heart patient, without adding carnitine to the mix. This is because carnitine, an important "heart" amino comes from lysine, and lysine is antagonistic with arginine. It is also probably necessary to supplement with zinc to one with copper when adding arginine, as zinc is depleted with large doses of arginine, and the mineral is vitally needed to make hundreds of enzymes and along with betaine activate the heart protectors, folic acid, B12 and B6. With excess arginine and depletion of zinc, homocysteine could build up. This could account for the adverse results of sole arginine loading. This means as well that if one takes arginine, methionine and B6 should go hand in hand. Aminos have to be balanced.