Silicon Investor (SI) -- The First Internet Community

STOCKTALK

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor. We ask that you disable ad blocking while on Silicon Investor in the best interests of our community. If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.

Strategies & Market Trends : Mish's Global Economic Trend Analysis -- Ignore unavailable to you. Want to Upgrade?

To: orkrious who wrote (58784)	10/31/2006 12:13:49 PM
From: regli	Read Replies (1) \| Respond to of 116555

No, I don't. I am very familiar with Quickbooks and out of habit never moved away from it despite the free MS version. I am certain there are a lot of people in the same boat and this is why MS is giving the express version away for free.

To: orkrious who wrote (58784)	11/1/2006 1:33:29 PM
From: ild	Respond to of 116555

Ingredient in Red Wine May Counter Fatty Diet By DAVID STIPP November 1, 2006 12:08 p.m. A substance in red wine previously shown to slow aging in several animal species may help prevent adult-onset diabetes and block other deleterious effects of fattening diets, according to a mouse study published online today by the journal Nature. While not showing that the compound, resveratrol, had antiaging effects in mice, the study suggested that it mimics some of the effects of calorie restriction, or CR -- the only established way to slow the aging process. CR entails cutting normal calorie intake by a third or so to slow aging. Discovered in the 1930s, it has been shown to extend longevity by 30% to 40% in animals. Monkey and human studies suggest it probably also can extend human longevity. But few people can take its hunger pangs. Thus, drugs that mimic its ability to lower the risk of many diseases of aging -- and potentially to extend human life span -- are considered the best bet to bring its benefits to the masses. The new study indicated that resveratrol-based drugs may yield at least some of those benefits, regardless of whether it mimics CR. Besides warding off various ill effects of high-calorie diets in mice, resveratrol gave the animals a major survival advantage over undosed control animals. The mortality reduction observed so far closely tracks a study on calorie-restricted mice that ultimately had a 20% lifespan extension, according to the study, which was conducted by researchers at Harvard Medical School and the National Institute on Aging, part of the National Institutes of Health. The life-span extension, however, didn't prove that resveratrol slows aging -- blocking the ill effects of a fattening diet is not the same as retarding the normal process of aging. But it did suggest that the substance may lead to drugs that retard the onset or help alleviate a wide array of diseases linked to obesity, which would make them very valuable. About a fourth of Americans are afflicted with metabolic syndrome, a constellation of obesity-related ills that often leads to diabetes and heart attacks. Hopes that resveratrol might yield CR's gain without pain were first raised in 2003 by Harvard Medical School biologist David Sinclair, who led a study showing that the compound boosted yeast cells' lifespan by 70%, apparently by mimicking CR. Subsequent studies showed that it also has antiaging effects in roundworms, fruit flies and a species of short-lived fish. That set the stage for the new mouse study, spearheaded by Dr. Sinclair, whose data represent the first detailed examination of resveratrol's possible CR-like effects in mammals. The new study's data paralleled those obtained in another investigation of resveratrol's effects in mice on fattening diets that was reported at a recent scientific meeting by Sirtris Pharmaceuticals Inc., a Cambridge, Mass., biotech startup co-founded by Dr. Sinclair. Besides lowering the risk of diabetes, according to Sirtris's rodent data, resveratrol and like-acting drugs may limit weight gains from rich diets. Sirtris recently began testing a resveratrol-based drug in diabetic patients. (Sirtris's chief executive, Christoph Westphal, is married to a reporter for The Wall Street Journal.) Although resveratrol is found in red wine, and is also available in over-the-counter dietary supplement pills, the doses used in the mouse study were far higher than those available from these options. Resveratrol pills haven't been tested in large clinical trials, so their efficacy isn't proven, nor is it clear what dose would yield desired effects.