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Biotech / Medical : Dynavax DVAX -- Ignore unavailable to you. Want to Upgrade?

To: nigel bates who wrote (43)	1/8/2007 7:17:37 PM
From: keokalani'nui	Respond to of 184

BERKELEY, Calif., Jan. 8 /PRNewswire-FirstCall/ -- Dynavax Technologies Corporation (Nasdaq: DVAX) announced today that the analysis of interim one-year data from its two-year DARTT ragweed allergy trial indicated that no meaningful ragweed-specific allergic disease was observed in the study population, making it impossible to measure the therapeutic effect of TOLAMBA treatment. In all three arms of the study, including the placebo arm, minimal change from baseline was observed in the main efficacy measure of the study, the total nasal symptom score (TNSS). The company indicated that in the placebo and treated groups, the change from baseline TNSS was very low; not clinically significant; and substantially lower than what has been observed in prior trials. "In effect, we saw three patient groups with no measurable disease during the ragweed season. This result was unexpected, though these challenges are well known to occur in allergy drug development. Due to the fact that no clinically significant disease was seen in the study population, it was impossible to measure the effect of our intervention," noted Dino Dina, MD, president and chief executive officer. Dina continued, "We are working closely with our consultants and investigators to review the data in detail and determine the future of the program." "In addition to the allergy franchise, we have a diverse pipeline of TLR9 agonist based programs, including an ongoing pivotal Phase 3 trial evaluating our hepatitis B vaccine, two clinical cancer studies, and exciting preclinical work in flu, anthrax, hepatitis, and asthma. Our partnerships with AstraZeneca, Symphony, and the NIH, and a cash position in excess of $100 million provide a strong foundation for moving forward to capitalize on our robust portfolio of near- and longer-term commercial opportunities," he noted.