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Biotech / Medical : ACADIA Pharmaceuticals Inc (ACAD) -- Ignore unavailable to you. Want to Upgrade?


To: NeuroInvestment who wrote (385)1/16/2007 3:46:29 PM
From: tuck  Respond to of 588
 
Digging around some more, I find a study that seems to contradict the recent Natesan et. al. study that I pointed to on at least one front. Natesan et. al. found little Fos induction in the nucleus accumbens, but these guys found noticeable Fos induction there:

nature.com

So who's right? How important is that parameter is in predicting efficacy?

As for the agranulocytosis issue . . . Harry has probably seen these, but for the rest of us . . . in reference to the studies cited in the Lehman note posted by George, here's a couple of related full text freebies. The ones actually cited in the Lehman note are abstracts only unless you pay.

molpharm.aspetjournals.org

molpharm.aspetjournals.org

Cheers, Tuck