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To: Mike McFarland who wrote (59)	5/22/2007 1:09:01 PM
From: Mike McFarland	Respond to of 379

Just picking my way around hedgehog's blog, this is put together pretty well and probably worth a read and the effort to snag the papers. pathway2curis.com A lot of IFs for sure, but good reading... snippets of snips If cancer stem cells arise from tissue stem cells, and if Hh and Wnt pathway activities are critical for the renewal of at least some of these stem cell types, then continuous Hh and Wnt pathway activities may promote cancer growth by continuously recapitulating their roles in promoting normal stem cell renewal aspects of systems biology come to mind Of course, multiple genetic or epigenetic changes might be required to trap the activated stem cell initially, and numerous other events may contribute to rapid proliferation or to other aspects of the phenotype. scary stuff... pathway-blocking agents that do not cross the blood/brain barrier Anyway, the url for the pdf at the end of the entry is dead, but I'll try to figure out what paper it is.