To: LindyBill who wrote (1335 ) 7/31/2007 3:25:12 AM From: E. Charters Respond to of 17085 As I said there is a price to pay with those drugs and they are not preferred to folic acid. I believe they are more expensive as well. Colchicine can impair the stomach lining. It is more serious in other ways. Read on. If you still want to stay with these dangerous and expensive drugs in preferrence to a harmless vitamin that will have the side effect of reducing cancer and heart disease I will leave that choice to you. There is a chance that the water retention could (have been) be helped substantially by losing weight, B1, B6, COQ10, glucosamine sulfate, vitamin C, Quercetin and L-Carnitine. This is a shotgun approach. I suspect your heart was causing it. Have you got a distinct crease in your earlobe? If you do, then you should eat celery, onions and garlic to excess and drink pomegranate, and eat blueberries every day. Cut out all fats, sodium foods, anything in a package, and cut back on protein drastically. Wipe veggie oil out of your diet, and walk 3 miles a day. Report back in 3 month and tell me how you feel. Regardless of staying on your gout therapy, you should increase your folate and b12 and b vitamin load drastically. Never mind the VITAMIN STUDY reports in the pop press. There is ABSOLUTE PROOF THAT FOLATE AND B12 REDUCE CANCER AND HD. IT IS THE CURVE OF THESE DISEASES SINCE THE FDA MANDATED THE SUPPLEMENTATION OF THESE ELEMENTS IN WHITE BREAD IN 1989. pubmedcentral.nih.gov It could have been the thyroid and possibly the kidneys. Gout and water retention at your age is a symptom of HD. ************************************************ COLCHICINE SIDE EFFECTS Adverse reactions in decreasing order of severity are: bone marrow depression, with aplastic anemia, with agranulocytosis or with thrombocytopenia may occur in patients receiving long-term therapy. Peripheral neuritis, purpura, myopathy, loss of hair, and reversible azoospermia have also been reported. Vomiting, diarrhea, and nausea may occur with colchicine therapy, especially when maximal doses are necessary for a therapeutic effect. To avoid more serious toxicity, the drug should be discontinued when these symptoms appear, regardless of whether or not joint pain has been relieved. Dermatoses have been reported. Hypersensitivity reactions may occur infrequently. DRUG INTERACTIONS Colchicine is inhibited by acidifying agents. The action of colchicine is potentiated by alkalinizing agents. Colchicine may increase sensitivity to the CNS depressants. Response to sympathomimetic agents' may be enhanced by colchicine. ALUPIRINOL SIDE EFFECTS What side effects can this medication cause? Allopurinol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: * upset stomach * diarrhea * drowsiness Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately: * skin rash * painful urination * blood in the urine * irritation of the eyes * swelling of the lips or mouth * fever, sore throat, chills, and other signs of infection * loss of appetite * unexpected weight loss * itching Allopurinol may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. **************************************************