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Biotech / Medical : Biocryst Pharmaceuticals Inc (BCRX) -- Ignore unavailable to you. Want to Upgrade?

To: Ian@SI who wrote (176)	9/20/2007 5:31:19 PM
From: Archie Meeties	Read Replies (2) \| Respond to of 269

Ok if they were measuring CK's why didn't they catch on to the fact that some were not getting an im dose while the study was ongoing?

To: Ian@SI who wrote (176)	9/20/2007 5:48:37 PM
From: mopgcw	Read Replies (2) \| Respond to of 269

i added to my position here. the study is externally funded, and i think further downside very limited. take care george

To: Ian@SI who wrote (176)	9/20/2007 8:29:23 PM
From: kenhott	Read Replies (2) \| Respond to of 269

As has been pointed out, BCRX looked and discovered the needle length + CK line of thinking after getting the results. Stonehouse is sounding confidence mostly I think because of prior data. He is saying we know it works, look at all the history and other positive data we have. BCRX does not have drug conc. # for this phase 2 unfortunately. Instead of going down the CK path, here is another path: BCRX was good enough to provide a PDF with the CC. On page 9 you will see a plot of BMI vs. CK change for drug-only patients on the right. You can see that most of the patients were BMI <30. So what is the data for BMI <30 or <25, etc. vs. BMI > 30, etc. etc.? I ask this because management's argument is based a lot on the patient group being too fat. So seems like the first logical cut should be on BMI. So did they look or not? I know they had time to look thru the data set. Obviously if BMI data agrees with CK then it paints a very congruent picture. About BMI: If you go to the below website: nhlbisupport.com You can get an idea what a BMI = 30 person might look like by putting in some numbers for weight and height and get a BMI~30. Try both a male and a female and think about the 1 inch needle. I didn't need the website, I just had to go and look in the mirror.