To: BulbaMan who wrote (2 ) 12/31/2007 5:42:16 PM From: pgo-neil Respond to of 322 Hi Bulba, Thank you for the value added weeklies last year. It was helpful to me and I thought provided good discussion stimulus. This year looks a lot like last year. Some companies that are already selling products and getting close to a profitable era. They didn't quite make it last year, so the odds have improved this year. :-) Others have some binary events looming that I tell myself are more likely than not. :-) :-( AMLN 10 37.00 BIIB 10 56.92 CRGN 5 0.92 CRXL 5 16.54 DNDN 10 6.22 ELN 15 21.98 EXEL 5 8.63 GNVC 5 1.47 INSM 5 0.825 JAZZ 5 14.70 MATK 10 29.58 NFLD 5 1.04 SEPR 10 26.25 I cannot remember a time in a paper portfolio or in real life when I had so many [potential] penny stocks. I wonder what this really means? I believe it is reflective of the broad market worries over credit quality and access to capital for money-losing biotechs. So if they have successful milestones that should translate into better prices. AMLN, BIIB, CRXL, ELN, MATK, and SEPR have the opportunity to grow revenues through organic growth or rolling up some smaller fish. Any except possibly ELN could be swallowed whole by a bigger fish. SEPR was a last minute addition brought about with the prospect of leadership change. DNDN and NFLD both have FDA events of the highly uncertain variety. I think that NFLD can deliver an Application for PolyHeme and have it accepted. Approved? Don't know. JAZZ has an Approval and and an Approvable in the last week. There is a modest pipeline. EXEL has a lot of potential with its trials, partnerships, and IP in the vault. I hope they kept none of David Robinson's habits. :-( :-) CRGN, GNVC, and INSM are more akin to selecting black at the roulette table. Each has some strengths and possible value. Each has a real problem [can they get to a successful milestone and raise cash before going bust]. I will say, I don't understand what CRGN's problem really is and for this reason nearly took it off, but the ratios are compelling. This would not be the first time I was seduced by the numbers. My charity is Engineers Without Borders [$150], they "partner with developing communities to improve their quality of life through the implementation of environmentally sustainable, economically sustainable, and equitable engineering projects, while developing internationally responsible engineers and engineering students." Many of their projects are important in raising the level of public health in their partner communities. ewb-usa.org Best, graham