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To: E. Charters who wrote (2667)	2/16/2008 5:06:19 PM
From: Joe NYC	Read Replies (1) \| Respond to of 17067

EC, "LDL poses a risk for cardiovascular disease when it invades the endothelium and becomes oxidized, since the oxidized form is more easily retained by the proteoglycans. A complex set of biochemical reactions regulates the oxidation of LDL, chiefly stimulated by presence of free-radicals in the endothelium. I think it is a little counter-intuitive that LDL cells just villy-nilly decide to stick to the walls of arteries, sometimes doesn't, just because more of them are in the blood stream. I think the other causes (smal LDL particles predominate, cholesterol is oxidized) are more likely triggers. Joe