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Biotech / Medical : MEDX ... anybody following? -- Ignore unavailable to you. Want to Upgrade?

To: Icebrg who wrote (1939)	2/20/2008 8:01:49 AM
From: Icebrg	Respond to of 2240

[Discussion of the results seen in the melanoma study (from the referenced PNAS paper)]. Notwithstanding the absence of clinical grade 3 or 4 inflammatory toxicities, 8 of the 11 subjects displayed meaningful antitumor effects, as measured by tumor regressions or prolonged stable disease, with associated improvements in disease-related morbidities (SI Table 1). By standard Response Evaluation Criteria in Solid Tumors (RECIST), three subjects demonstrated partial responses (Fig. 3). These regressions became apparent only after several months of therapy and were preceded by transient increases in tumor size early after antibody infusion. Regressions were observed in multiple visceral sites, including lung, pleura, intestine, and perirenal soft tissues, and these responses have proved durable (ongoing at 34, 24, and 21 months). By radiographic and clinical criteria, an additional five patients manifested stable disease for a minimum of 4 months and extending up to 25 months (the current length of follow-up). In light of the prior pace of disease progression and the significant tumor burden present in these patients upon initiation of anti-CTLA-4 antibody treatment (liver, lung, bone,visceral nodes, skin, and soft tissues), these antitumor effects are significant.