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Biotech / Medical : ACADIA Pharmaceuticals Inc (ACAD) -- Ignore unavailable to you. Want to Upgrade?

To: scaram(o)uche who wrote (493)	7/24/2008 2:05:46 PM
From: tuck	Respond to of 588

[ERb-131: Differential modulation of inflammatory pain by a selective estrogen receptor beta agonist.] >>Eur J Pharmacol. 2008 Jul 4. [Epub ahead of print] Differential modulation of inflammatory pain by a selective estrogen receptor beta agonist. Gardell LR, Hyldtoft L, Del Tredici AL, Andersen CB, Fairbairn LC, Lund BW, Gustafsson M, Brann MR, Olsson R, Piu F. ACADIA Pharmaceuticals Inc, San Diego, CA, USA. To understand the contribution of the estrogen receptor beta, the potent and selective agonist ERb-131 was evaluated in animal models of inflammatory pain. In paradigms of acute and persistent inflammatory pain, ERb-131 did not alleviate the nociception induced by either carrageenan or formalin. However, in the chronic complete Freund's adjuvant model, ERb-131 resolved both inflammatory and hyperalgesic components. Thus, ERb-131 is sufficient to alleviate chronic but not acute inflammatory pain states.<<