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Pastimes : Heart Attacks, Cancer and strokes. Preventative approaches -- Ignore unavailable to you. Want to Upgrade?

To: LindyBill who wrote (2378)	12/4/2008 6:42:52 PM
From: LindyBill	Read Replies (1) \| Respond to of 39298

The last post mentioned to BP meds. A good ACE inhibitor is Lisinopril, which I use. Here is an article on Calcium Channel Blockers. Calcium Channel Blockers (CCBs) Medical Author: Omudhome Ogbru, Pharm.D. Medical Editor: Jay Marks, M.D. What are CCBs and how do they work? Calcium channel blockers are a class of drugs that block the entry of calcium into the muscle cells of the heart and the arteries. It is the entry of calcium into these cells that causes the heart to contract and arteries to narrow. By blocking the entry of calcium, CCBs decrease contraction of the heart and dilate (widen) the arteries. In order to pump blood, the heart needs oxygen. The harder the heart works, the more oxygen it requires. Angina (heart pain) occurs when the supply of oxygen to the heart is inadequate for the amount of work the heart must do. By dilating the arteries, CCBs reduce the pressure in the arteries. This makes it easier for the heart to pump blood, and, as a result, the heart needs less oxygen. By reducing the heart's need for oxygen, CCBs relieve or prevent angina. CCBs also are used for treating high blood pressure because of their blood pressure-lowering effects. CCBs also slow the rate at which the heart beats and are therefore used for treating certain types of abnormally rapid heart rhythms. For what conditions are CCBs used? CCBs are used for treating high blood pressure, angina, and abnormal heart rhythms (e.g., atrial fibrillation). They also may be used after a heart attack, particularly among patients who cannot tolerate beta-blocking drugs, have atrial fibrillation, or require treatment for their angina. (Unlike beta blockers, CCBs have not been shown to reduce mortality or additional heart attacks after a heart attack.) CCBs are as effective as ACE inhibitors in reducing blood pressure, but they may not be as effective as ACE inhibitors in preventing the kidney failure of high blood pressure or diabetes. Are there any differences among CCBs? CCBs differ in their duration of action, the process by which they are eliminated from the body, and, most importantly, in their ability to affect heart rate and contraction. Some CCBs (e.g., amlodipine) have very little effect on heart rate and contraction so they are safer to use in individuals who have heart failure or bradycardia (a slow heart rate). Verapamil and diltiazem have the greatest effects on the heart and reduce the strength and rate of contraction. Therefore, they are used in reducing heart rate when the heart is beating too fast. What are the side effects of CCBs? The most common side effects of CCBs are constipation, nausea, headache, rash, edema (swelling of the legs with fluid), low blood pressure, drowsiness, and dizziness. When diltiazem or verapamil are given to individuals with heart failure, symptoms of heart failure may worsen because these drugs reduce the ability of the heart to pump blood. With which drugs do CCBs interact? Most of the interactions of CCBs occur with verapamil or diltiazem. The interaction occurs because verapamil and diltiazem decrease the elimination of a number of drugs by the liver. Through this mechanism, verapamil and diltiazem may reduce the elimination and increase the blood levels of carbamazepine (Tegretol), simvastatin (Zocor), atorvastatin (Lipitor), and lovastatin (Mevacor). This can lead to toxicity from these drugs. What CCBs are available? The CCBS that have been approved for use in the US include nisoldipine (Sular), nifedipine (Adalat, Procardia), nicardipine (Cardene), bepridil (Vascor), isradipine (Dynacirc), nimodipine (Nimotop), felodipine (Plendil), amlodipine (Norvasc), diltiazem (Cardizem), and verapamil (Calan, Isoptin). medicinenet.com