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To: Sea Otter who wrote (158372)1/17/2009 2:45:47 AM
From: stockman_scott  Respond to of 362352
 
Steve Jobs, Patrick Swayze raise awareness of deadly pancreatic cancer

nydailynews.com

BY ROSEMARY BLACK
NEW YORK DAILY NEWS STAFF WRITER
Updated Friday, January 16th 2009, 5:38 PM

It's a deadly disease with a dismally poor survival rate and so few initial symptoms that sufferers often don't know they have it until it's too late.

But awareness of pancreatic cancer is on the rise as two of its high-profile victims - Steve Jobs and Patrick Swayze - made headlines this week.

Swayze, diagnosed a year ago with the most common and grimmest form of the disease, was hospitalized with pneumonia last Friday. And Wednesday, a skeletal-looking Apple CEO Jobs, diagnosed with a less serious form of the illness in 2004, announced that he was taking a medical leave, prompting speculation that his cancer might have returned.

Sadly, a recurrence of pancreatic cancer is the norm, doctors say. The five-year survival rate is just 5 to 10 percent, and that includes patients whose tumors were small enough that they could have surgery. Each year, there are about 35,000 new cases of pancreatic cancer in this country, and about the same number of Americans die annually from the disease.

Current treatments have failed to increase the survival rates. Several new chemotherapy drugs are in use, but "there's certainly no breakthrough drug at this point," says Dr. Daniel Labow, surgical oncologist and assistant professor of surgery at Mt. Sinai Hospital. "Some of the drugs improve the quality of life but in general, they don't prolong it."

Medical experts are looking at the genetics of pancreatic cancer, and why some forms of this killer are so resistant. At Johns Hopkins Medical Center, scientists have successfully mapped the entire genetic blueprint for pancreatic cancer. The blueprint can show which forms of the disease are caused by smoking, which are caused by genes inherited from a parent, and which came about due to simple bad luck.

Such information could potentially be used to devise new therapies, says Dr. John Chabot, professor of clinical surgery at Columbia University. "Once you understand more about which genes and mutations are required for a tumor to grow, you can start to use drugs in a more logical way, and to give drugs that block the route of the cancer."

Taking into account family history could potentially save lives, Chabot says.

"If there is pancreatic cancer in a family, we can do scans on other family members," notes Dr. Chabot. "And in those people with premalignant changes to the pancreas, we can do surgery."

While tumors that are caught early are operable, the cancer still tends to recur. And many times the disease has spread too far when it's discovered. "Often when you get symptoms, it may be too late," Labow explains.

In terms of prevention, "There's not an awful lot you can do," says Dr. David Clain, acting chairman of digestive diseases at Beth Israel Medical Center. "There is a small increased risk of pancreatic cancer for smokers and people who eat a high fat diet, but that connection is small."

Pancreatic cancer exhibits few early symptoms that people can watch for. Jaundice is a major red flag, so if you develop yellow skin or eyes and have very dark urine, call your doctor right away, Labow says. Chronic diarrhea and unexplained weight loss are also symptoms - but they can be symptoms of many other disorders, too. This type of cancer is associated with age, and the peak of diagnosis is people in their sixties. Men are slightly more prone than women to develop this cancer.

In the cases of Swayze and Jobs, they've already more than beat the statistical odds.

"The vast majority of people with pancreatic cancer die within six months," says Dr. Clain.



To: Sea Otter who wrote (158372)1/17/2009 3:24:00 AM
From: stockman_scott  Respond to of 362352
 
Madoff's fund may not have made a single trade

reuters.com

Fri Jan 16, 2009 6:55am EST

By Jason Szep

BOSTON (Reuters) - Bernie Madoff's investment fund may never have executed a single trade, industry officials say, suggesting detailed statements mailed to investors each month may have been an elaborate mirage in a $50 billion fraud.

An industry-run regulator for brokerage firms said on Thursday there was no record of Madoff's investment fund placing trades through his brokerage operation.

That means Madoff either placed trades through other brokerage firms, a move industry officials consider unlikely, or he was not executing trades at all.

"Our exams showed no evidence of trading on behalf of the investment advisor, no evidence of any customer statements being generated by the broker-dealer," said Herb Perone, spokesman for the Financial Industry Regulatory Authority.

Madoff's broker-dealer operation, Bernard L. Madoff Investment Securities, underwent routine examinations by FINRA and its predecessor, the National Association of Securities Dealers, every two years since it opened in 1960, Perone said.

Madoff, a former chairman of the Nasdaq Stock Market who was a force on Wall Street for nearly 50 years, allegedly confessed to his sons the firm's investment-advisory business was "basically a giant Ponzi scheme" and "one big lie," according to court documents.

He estimated losses of at least $50 billion from the Ponzi scheme, which uses money from new investors to pay distributions and redemptions to existing investors. Such schemes typically collapse when new funds dry up.

Each month, Madoff sent out elaborate statements of trades conducted by his broker-dealer. Last November, for example, he issued a statement to one investor showing he bought shares of Merck & Co Inc, Microsoft Corp, Exxon Mobil Corp and Amgen Inc among others.

It also showed transactions in Fidelity Investments' Spartan Fund. But Fidelity, the world's biggest mutual fund company, has no record of Madoff or his company making any investments in its funds.

"We are not aware of any investments by Madoff in our funds on behalf of his clients," Fidelity spokeswoman Anne Crowley said in an e-mail to Reuters.

Neither Madoff nor his firm was a client of Fidelity's Institutional Wealth Services business, their clearing firm National Financial or a financial intermediary client of its institutional services arm, she said.

"Consequently, his firm did not work with our intermediary businesses through which firms invest their clients' money in Fidelity funds," she added.

There also appear to be discrepancies between monthly statements sent to investors and the actual prices at which the stocks traded on Wall Street.

For example, his November statement showed he bought software maker Apple Inc's securities at $100.78 each on November 12, about a month before his arrest.

But Apple's stock on that day never traded above $93.24. The statement also showed he bought chip maker Intel Corp at $14.51 on November 12, but Intel's highest price on that day was $13.97.

"You could print up any statements you want on the computer and send it out to a client and the chances are the client wouldn't know, because they are getting a statement," said Neil Hackman, president and chief executive of Oak Financial Group, a Stamford, Connecticut-based investment advisory firm.

To some, the numbers did not add up.

About 10 years ago, Harry Markopolos, then chief investment officer at Rampart Investment Management Co in Boston, asked risk management consultant Daniel diBartolomeo to run Madoff's numbers after Markopolos tried to emulate Madoff's strategy.

DiBartolomeo ran regression analyses and various calculations, but failed to reconcile them. For a decade, Markopolos raised the issue with the U.S. Securities and Exchange Commission, which has come under fire in Congress in recent weeks for failing to act on Markopolos's warnings.

(Additional reporting by Muralikumar Anantharaman; Editing by Andre Grenon)



To: Sea Otter who wrote (158372)1/17/2009 2:54:47 PM
From: stockman_scott  Respond to of 362352
 
Forecasts 2009, IT Companies: Intel, Apple, Microsoft

havemacwillblog.com

Posted on January 13th, 2009 by Robin Bloor in IT Trends

It will not be surprising if every vendor I mention here sheds staff this year. Staff cuts and revenue reductions are poor ways to judge the success of companies in these parlous times. The economy is messing with our metrics. We should judge success by:

1. Movements in market share

2. Sustainability of business strategy

3. The profitability picture (not short term, but over the medium term - because there may be quarters where profits vanish into necessary restructuring)

Having said that, let’s consider the situation of Intel, Apple and Microsoft in that order…

Intel

Intel presents a mixed picture. It has done serious competitive damage to AMD in the x86 market. So in terms of market share, the situation looks positive, despite the fact that Intel’s revenues will inevitably suffer to some degree this year. The competitive challenge for Intel is that it must now compete with Nvidia and AMD’s subsidiary ATI in the graphics market. Graphics is where the action is on PCs, Macs and laptops, because the graphics card is doing most of the work. (To be honest you could put a puny cpu in many of these devices and as long as you plugged in sufficient memory and a powerful graphics card, the user wouldn’t notice.)

In theory Intel should be feeling the heat in the graphics market from both Nvidia and ATI, who appear to have superior technology. Nevertheless, Intel dominates the market and it actually increased its market share last year. It now has 47.3% of all desktop and notebook graphics, mainly because it has 57.1% of the notebook market - and that by the way, is the market that’s growing.

Aside from these competitors, there’s also IBM, which - just in case you hadn’t noticed - has about 100% of the home games machine market (if you only count the most recent consoles from Sony, Nintendo and Microsoft.) As far as chips are concerned, IBM, like Intel, AMD and Nvidia is all about graphics. Ultimately, a computer game is 99.99% graphics and the most advanced graphics applications from that perspective run on IBM chips. There can be little doubt that IBM will ultimately come into direct competition with these other players. The battleground for that fight will most likely be around the “home entertainment center.” It’s too early to know how that market will pan out.

In my view Intel is doing better than it could have expected and that may be due to the effective leadership of Paul Otellini. I don’t think we need be concerned for Intel this year, unless we witness its market share slipping in any of its important markets.

Apple

My coverage of Apple is on-going so I’ll just upgrade it a little here. In case you’re unaware of it, my view is that Apple has broken Microsoft monopoly irreversibly, with the consequence that it can no longer be stopped in the desktop market or the laptop market. Microsoft, Dell, HP et al will simply have to get used to Apple having a growing share of those markets (by revenue.) I’d go as far as to say that “the Mac is now a saloon car, while the PC is a small run-around.” The products are not really in direct competition. If you want a Mac then you don’t really want a PC - and vice versa.

The more interesting aspect of Apple is that the iPhone is a much bigger success than anyone (including Apple) ever expected it to be. Apple has single-handedly recreated the mobile phone market and recreated it in its own image. The App Store is a huge success that must be dispiriting for RIM and Nokia (the two also-rans in this market.) It was bad enough for them that Apple redefined what a mobile phone should be, now they’ve redefined what the business model should be. The mobile market is going to be important this year because preliminary signs indicate that it may not stop growing - at least in terms of corporate investment.

In a way it’s logical. There’s a technology revolution going on that reminds me a little of the application avalanche that occurred as the PC market developed. The old mobile phone is dying and now everyone and his country cousin wants to be in on the new device, which is at once (and by varyng degrees):

A mobile phone
A PDA
A geographical reference resource with GPS
A games machine
A web access device
A music/video player
An ebook reader
A camera

From here on in, it’s Apple’s to lose and there’s no indication that it will lose it. Most likely it will establish a monopoly that’s every bit as solid as it’s iPod monopoly has proved to be. The iPod is, of course, starting to fade, but the iPhone is much more powerful.

The recession will not stop Apple’s momentum, even if it succeeeds in holding down its share price.

Microsoft

Microsoft is looking very much like a sunset company these days. It was no secret in Redmond or anywhere else that it needed to go beyond the gushing revenues streams of Windows and MS Office and reinvent itself. It’s a rare event in industrial history that any vendor gets to be in such a powerful position as Microsoft achieved in the 1990s and it’s more than surprising that it has failed so clearly to carve out more territory.

Taking it piece by piece:

Server market: In the server market Microsoft has done really well. As far as business growth and technology direction is concerned, it has performed powerfully after a faltering start. This area of its business remains healthy, is populated by good products and is much to be admired.
The XBox: Had it not been for a surprising innovation from Nintendo, the XBox would now be the dominant games console and qualify as yet another stellar Seattle success. You cannot even accuse Microsoft of having failed to innovate. Microsoft has done well. It’s just that Nintendo did far better.
The Web: Microsoft has compeltely failed to dent Google’s dominance. Despite Ray Ozzie’s new initiative and his unbridled optimism, this is unlikely to change any time soon.
The Mobile World: Game, set and match to Apple.

That’s a mixed pciture and none of it would matter much were it not for the threatened state of the jewels in the Microsoft crown; Windows (as a PC OS) and MS Office (as PC Apps). Both of these are now under threat.

Windows Vista quite simply failed to compete with Apple’s OS X. This broke the Windows monopoly. So far it’s not as much of a disaster as it could be. Microsoft cannot compete effectively with Apple, because Apple does the whole business stack from the iron to the apps, including the channel to market. Apple can innovate at points in that stack where Microsoft has no position - and it does (think hardware design, think Apple Stores, think iTunes, etc.) The truth is that Microsoft cannot actually compete effectively with Apple at all.

This is not as much of a disaster as it might be, because Apple doesn’t want to own the PC market. But Microsoft’s partners (Dell, HP, Acer et al) are hurting. There is a possibility that one or two of them will hitch their wagon to PC linux in one of its varieties and head off in a non-Microsoft direction. Microsoft has played a very effective game of whack-a-mole (or whack-a-penguin perhaps) with Linux so far, smacking it down wherever it crops up. The more successful Apple is, the less likely that a whack-a-mole strategy will work against Linux.

The brightest jewel in the Microsoft crown is MS Office. There’s little doubt that MS Office in its various forms (Star Office from Sun, Open Office and Lotus Symphony) is drawing some users away from Microsoft and so are Zoho and Google Apps, but so far it doesn’t really qualify as a haemorrhage. If and when it does, there will be wailing and gnashing of teeth in Redmond.



To: Sea Otter who wrote (158372)1/17/2009 9:09:33 PM
From: stockman_scott  Read Replies (1) | Respond to of 362352
 
Sea Otter: Jobs is more important to Apple than Gates was to Microsoft. Anyone who doesn't see the difference doesn't understand what Steve Jobs really brings.

It's not his design sense, etc...it's his absolute refusal to put out something that's not as good as he thinks it can be.

That attitude is incredibly rare in business where there's a lot of 'get it out the door and get some $$ in the bank, we can fix it later' going around. Steve Jobs pushes people to do better than they know they can and the risk if he doesn't return is that no other executive will be so insane about this. And even if they are...Jobs FOUNDED Apple. That gives him a power that no one else can really duplicate, one that's rooted in something that no other exec can have no matter how bright or good that exec is.

Will Apple survive if Jobs leaves permanently? Yes. Will they continue to be special and put out things that change how people use technology? Maybe.



To: Sea Otter who wrote (158372)3/5/2009 7:21:03 PM
From: stockman_scott  Read Replies (1) | Respond to of 362352
 
Obama's CIO choice could cause big headaches for Microsoft

techflash.com

By John Cook on March 5, 2009 at 11:24 PST

Barack Obama' s choice of Vivek Kundra as the nation's first chief information officer may not be greeted warmly in Redmond, since the 34-year-old is described as an energetic BlackBerry-toting enthusiast of Google and Apple. As the Chief Technology Officer for the District of Columbia, Kundra just last summer signed a deal with Google to move the district's 38,000 employees to cloud-based applications. At the time, Ars Technica wrote that it was "yet another blow to Microsoft's incumbent office suite."

Could Kundra try to implement a similar program nationwide? In a conference call today, Kundra expressed an interest to expand the government's use of cloud computing. Microsoft, which is trailing Google and Amazon.com in that arena, obviously will be paying close attention to those efforts and making its case in D.C.

Still, the appointment of Kundra prompted a TechFlash reader to wonder if the choice was driving Microsoft's stock lower today. "Ballmer just got another concern to add to his plate," the reader wrote in yesterday's story on Steve Ballmer's thoughts on innovation and the economy.