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Biotech / Medical : Biotech Valuation -- Ignore unavailable to you. Want to Upgrade?

To: Biomaven who wrote (30885)	4/10/2009 4:58:28 PM
From: IRWIN JAMES FRANKEL	Respond to of 52153

>>But they do make a good point that things are often more complicated than they seem ... That is what I thought the study illustrated. It makes you question what you really know. :-) ij

To: Biomaven who wrote (30885)	4/11/2009 12:36:29 AM
From: Clarksterh	Read Replies (1) \| Respond to of 52153

The nuclear factor {kappa}B (NF-{kappa}B) transcription factor regulates cellular stress responses and the immune response to infection. NF-{kappa}B activation results in oscillations in nuclear NF-{kappa}B abundance. To define the function of these oscillations, we treated cells with repeated short pulses of tumor necrosis factor–{alpha} at various intervals to mimic pulsatile inflammatory signals. At all pulse intervals that were analyzed, we observed synchronous cycles of NF-{kappa}B nuclear translocation. Lower frequency stimulations gave repeated full-amplitude translocations, whereas higher frequency pulses gave reduced translocation, indicating a failure to reset. If that is the abstract what does the body of the paper look like? (Seriously, I read that abstract in Science and it took me a minute or two to translate - I am thankful for the intro stories that exist for many of the papers (although I don't remember that particular paper having such an intro story))

To: Biomaven who wrote (30885)	4/11/2009 6:08:43 PM
From: BulbaMan	Read Replies (1) \| Respond to of 52153

Another reason not to give much credence to the report is the claim by one of the paper's co-authors, Amy Proal, that:"Vitamin D is currently being recommended at historically unprecedented doses. Yet at the same time, the rate of nearly every autoimmune disease continues to escalate." I strongly doubt that more than a tiny fraction of the public is taking vitamin D in "historically unprecedented doses." And there are so many other variables out there that are more likely to be associated with the increase in autoimmune disease. For example, the increasing use of sunscreens that more effectively block UV rays.