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Politics : THE WHITE HOUSE -- Ignore unavailable to you. Want to Upgrade?

To: DuckTapeSunroof who wrote (25565)	7/24/2009 3:35:49 AM
From: Gersh Avery	1 Recommendation Respond to of 25737

From one of our patients today: "Today was a good day. We saw another oncologist today. The appointment took a bit longer then we had planned. It seems the Clinic Director had caught wind of my progress and joined the visit towards the end. I don't know if they say that to all the patients, but I'll gladly take another doc being impressed with my progress. Take that Urgo! We were able to drop 1 med all together and made plans for what will start going away next. NICE." Stage IV brain cancer. Consumed hemp oil in combination with radiation/chemo. Oil consumption began a week before the r/c was started. Procedure monitored by the doctors. They were aware that the patient was insistent about using cannabis during treatment. They didn't realize the dosage levels at first. When they found out how much he was consuming they were shocked. The guy had sat through a class that I ran teaching people how to make this medicine only about two weeks before the cancer was discovered. While eating at a Starbucks he had a seizure. They found a large tumor in his brain that was moving into his motor skill area. They took out about 2/3 of it ASAP. He continued to have seizures until I got there. That night he slept 8.5 hours. From that time forward he never had another seizure. The dosage level started out with about 50 mg cannabinoids four times per day. Then ramped up to a max of about 250mg x 4. They hit him with some pretty massive dosages of steroids. It was expected that his blood sugar would jump up a lot as a result. Never happened. At one point he had to stop taking his blood pressure medicine. All nicely documented.

To: DuckTapeSunroof who wrote (25565)	7/27/2009 11:27:24 AM
From: Gersh Avery	1 Recommendation Read Replies (1) \| Respond to of 25737

Hi folks. I've been meaning to get around to introducing my self and posting whatever relevant information may help people who are thinking about trying the Rick Simpson method. As my mind is still not as clear as i would like (not from the oil) I'm hopeful Peanutbutter will clarify or correct any info I messed up. More will be coming soon. It's never going to be perfect so for now . . . Hello, I'm Greg Piasecki, A 41 year old male and a qualified Michigan Medical MJ Patient and President of Oakland County NORML out here in Michigan. Short version - May 12, 2009 I had a Grand Mal seiziure, lost consciousnous and found out I have stage IV GBM (primary). I have had no other known incidents of cancer and no previous symptoms. A golf ball sized mass Approx. 3.65 cm in dia and deep in the right side. 66% resected May 15th. In ICU through 22nd of May, released home May 26th. 30 treatments of radiation and chemo with 200 mg of Temadar/ day 5 days/ week began June 2 with the final radiation treatment July 14th . I am currently in a break period waiting to start my next course of chemotherapy with 400 mg of Temadar for 5 days on with 25 off/ month for approximately a year. A follow up MRI is scheduled for sometime in August. I don't have the original emergency room CT and MRI in my possession but i do have my baseline CT they took 4 days before chemo and rad began and providing access to my medical records is easy enough. Through my involvement with Oakland County NORML I had been reading and sharing various cannabinoid research pieces starting with the Compultense University studies on GBM’s Beginning with the early study in 2004: ScienceDirect - Neuropharmacology : Hypothesis: cannabinoid therapy for the treatment of gliomas? Hypothesis: cannabinoid therapy for the treatment of gliomas? Guillermo Velasco, Ismael Galve-Roperh, Cristina Sánchez, Cristina Blázquez and Manuel Guzmán, Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Avenida Complutense, sn, 28040, Madrid, Spain Received 21 January 2004;* Revised 25 March 2004;* accepted 22 April 2004.* Available online 10 July 2004. Abstract Gliomas, in particular glioblastoma multiforme or grade IV astrocytoma, are the most frequent class of malignant primary brain tumours and one of the most aggressive forms of cancer. Current therapeutic strategies for the treatment of glioblastoma multiforme are usually ineffective or just palliative. During the last few years, several studies have shown that cannabinoids—the active components of the plant Cannabis sativa and their derivatives—slow the growth of different types of tumours, including gliomas, in laboratory animals. Cannabinoids induce apoptosis of glioma cells in culture via sustained ceramide accumulation, extracellular signal-regulated kinase activation and Akt inhibition. In addition, cannabinoid treatment inhibits angiogenesis of gliomas in vivo. Remarkably, cannabinoids kill glioma cells selectively and can protect non-transformed glial cells from death. These and other findings reviewed here might set the basis for a potential use of cannabinoids in the management of gliomas. Bring us 5 years into the future and we arrive here: Journal of Clinical Investigation -- Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells Published in Volume 119, Issue 5 (May 1,2009) J. Clin. Invest. 119(5): 1359-1372 (2009). doi:10.1172/JCI37948. Copyright © 2009, The American Society for Clinical Investigation Research Article Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells Autophagy can promote cell survival or cell death, but the molecular basis underlying its dual role in cancer remains obscure. Here we demonstrate that ?9-tetrahydrocannabinol (THC), the main active component of marijuana, induces human glioma cell death through stimulation of autophagy. Our data indicate that THC induced ceramide accumulation and eukaryotic translation initiation factor 2a (eIF2a) phosphorylation and thereby activated an ER stress response that promoted autophagy via tribbles homolog 3–dependent (TRB3-dependent) inhibition of the Akt/mammalian target of rapamycin complex 1 (mTORC1) axis. We also showed that autophagy is upstream of apoptosis in cannabinoid-induced human and mouse cancer cell death and that activation of this pathway was necessary for the antitumor action of cannabinoids in vivo. These findings describe a mechanism by which THC can promote the autophagic death of human and mouse cancer cells and provide evidence that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers. Add in the nueroprotective, anti-inflamitory, anti-seisiure, apatite stimulation, and anti-nausea properties, blood pressure and blood sugar modulation on top of being able to finally sleep and increasing my odds of sticking around for my family and friends. Through the wonderful help of some amazing people*may 23rd and speaking with my most of my doctors I started taking an alternative cannabis treatment commonly referred to as the ‘Rick Simpson method’ before getting out of ICU and Run from the cure to my family. There are 2 points to this insanely long post, (Hope I put it in the right spot). Firstly, After surgery, they didn’t know if I was going to make it to September 2009. After only 9 weeks of conventional therapy AND the Simpson Oil I appear to be farther along then ANY of my doctors or nurses ever expected. Can’t wait for the next MRI when they are scratching their heads looking for more cancer bits. Secondly, I’m looking for researchers, physicians, etc. that can somehow use my info. Michael’s older posts pointed to a doc that didn’t pan out. Since then, he and a few others, thankfully, sent me here! If someone can use my info let's do this, that's the whole point. I'm guessing all I need to do is sign some HIPPA forms and that will provide access needed? General info and background here: caringbridge.org Take care and thanks for being out there. Greg Piasecki greenpassion.org To be clear, I may take a bit longer to get back with folks then normal right now. Peanutbutter is free and encouraged to discuss anything about my interesting jouney if he would like. Thanks, More to come soon.