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To: Suma who wrote (6159)8/5/2009 2:20:26 PM
From: pheilman_  Respond to of 39359
 
Suma,

Just an engineer's thoughts here: If you are changing the inputs and getting no results, seems like there is a feedback loop that has an incorrect setpoint and is fighting you. I would think that your kidneys are how sodium leaves the body. So now why would they have a wrong setpoint? (as expressed in the concentration of sodium in urine) I don't think there is a sodium pump in the gut so that wouldn't be the path. Sweat?
I see expected serum range is 135-145, there has to be a "control" system to keep it that tight.
What adjusts the setpoint for sodium pumping in the kidneys?
Wiki says it is Atrial natriuretic peptide, generated in the heart which decreases sodium reabsorption in the kidney. So if there is too much ANP, the kidneys don't save the sodium. Not really an answer but a line of inquiry.