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To: Jim McMannis who wrote (101923)	9/14/2009 3:54:22 PM
From: Elroy Jetson	Read Replies (1) \| Respond to of 116555

Thick Irish oats will have a lower Glycemic Index than do more processed instant oats. When your body has to expend more energy to extract the starches and convert them into sugar, the net caloric intake is less and the sugar inflow has a lower peak and is spread out over a longer period of time. My Doctor was a big promoter of Irish oats for breakfast. But when he tried replacing his Irish oats with eggs, at my suggestion, his Triglyceride level dropped significantly, and his LDL and Total Cholesterol level also declined slightly. So he has now taken to calling patients with high Triglyceride levels "carb eaters" and prescribes Lovaza (prescription fish oil) for them if they refuse to change their diet. .

To: Jim McMannis who wrote (101923)	9/14/2009 4:13:06 PM
From: Elroy Jetson	1 Recommendation Read Replies (1) \| Respond to of 116555

Two recent studies of Fructose from MedLine. . Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans ncbi.nlm.nih.gov J Clin Invest. 2009 May;119(5):1089-92 Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans, overweight and obese subjects consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Although both groups exhibited similar weight gain during the intervention, visceral adipose volume was significantly increased only in subjects consuming fructose. Fasting plasma triglyceride concentrations increased by approximately 10% during 10 weeks of glucose consumption but not after fructose consumption. In contrast, hepatic de novo lipogenesis (DNL) and the 23-hour postprandial triglyceride AUC were increased specifically during fructose consumption. Similarly, markers of altered lipid metabolism and lipoprotein remodeling, including fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant-like particle-triglyceride and -cholesterol significantly increased during fructose but not glucose consumption. In addition, fasting plasma glucose and insulin levels increased and insulin sensitivity decreased in subjects consuming fructose but not in those consuming glucose. These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults. Combination of Captopril and Allopurinol Retards Fructose-Induced Metabolic Syndrome. ncbi.nlm.nih.gov Am J Nephrol. 2009 Aug 21;30(5):399-404. [Epub ahead of print] Background: Both ACE inhibitors and allopurinol have been shown to partially prevent metabolic syndrome induced by fructose. We tested the hypothesis that combined therapy might be more effective at blocking the metabolic syndrome induced with fructose. Methods: Male Sprague-Dawley rats were fed a high fructose diet with or without allopurinol, captopril, or the combination for 20 weeks. A control group received a normal diet. All groups were pair-fed to assure equivalent caloric intake. Results: Despite reduced energy intake, the fructose-fed rats developed features of metabolic syndrome including elevated blood pressure, abdominal obesity, hypertriglyceridemia, hyperuricemia and hyperinsulinemia. While both allopurinol and captopril alone tended to reduce features of the metabolic syndrome, the combined therapy was synergistic, with significant reduction in blood pressure, less accumulation of abdominal fat, an improvement in the dyslipidemia and a complete prevention of insulin resistance. Conclusion: A high fructose diet can induce metabolic syndrome even in the setting of caloric restriction. Captopril and allopurinol synergistically reduce features of the metabolic syndrome, especially hypertension, insulin resistance and dyslipidemia. Combination allopurinol and ACE inhibitor therapy might provide a superior means to prevent diabetes and cardiovascular disease. .