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Biotech / Medical : Ligand (LGND) Breakout! -- Ignore unavailable to you. Want to Upgrade?

To: Henry Niman who wrote (10423)	10/30/1997 6:30:00 PM
From: squetch	Respond to of 32384

Henry, According to a 6/97 Goldman report by Maykin Ho, LLY is conducting two PIIIs for CTCL. The first study has completed enrollment w/ an NDA hoped for in second half of '97. The enrollment in the second CTCL is expected to be completed in second half of '97. PI/II results for psoriasis are expected by year end. Also a PI/II of second product DAB389-EGF in NSCLC has been started. The financing of SRGN appears quite yucky and convoluted to me. I think there are little over 20M shares outstanding. RE VD post Was that your 10K buy on SRGN near the close?(:>) Stan

To: Henry Niman who wrote (10423)	10/30/1997 6:49:00 PM
From: squetch	Read Replies (1) \| Respond to of 32384

There is a 5.1.95 WSJ article on psoriasis indication. Says there was a Nature Medicine article that maybe somebody could dig up? IN the study 4/10 psoriasis subjects had "striking" reduction of scaliness, itching and other symptoms, w/ a fflicted patches of their seeming return to normal. Another 4 had moderate improvement. SRGN's drug knocks out certain immune cells, and the patients w/ the most improvement were ones in which abnormal immune-cell activity in the skin was most reduced. The study's results are the stronges evidence that misguided immune attack underlie psoriasis, Dr. Krueger said. He indicated the drug could alleviate psoriasis "for a considerable time," perhaps many months. ... The drugs selective punch to the immune system isn't expected to cause serious side effects. The main effect appeared to be flu-like symptoms. I have some stuff that I'll try to post later.