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Biotech / Medical : Immunomedics (IMMU) - moderated -- Ignore unavailable to you. Want to Upgrade?

To: targetedmoab who wrote (8344)	11/26/2009 11:34:48 AM
From: idahoranch1	1 Recommendation Respond to of 63289

No problem at all, I appreciate honest points of view whether they line up with mine or not. Yours was and is valid and it would be easy for the kind of post I made to be out of line and done with wrong motives and with disregard for the patients referenced in the post. What I'm finding with regard to the three patients that I am communicating with is that the biggest thing facing them is what to do after hPAM4. They can only get so much radiation from that treatment and then, no matter how good the response, they have to figure out what to do next. This problem is faced as soon as they are done with the last treatment. Of course the hope is that they respond so well that the cancer is gone, and we all hope that happens, but reality is that if it does it will be in a small percentage of patients. The vast majority will be starting down a path that is uncharted. Since it seems to me that a good percentage of patients at 12mc are going to have good responses to hPAM4, and significant quality time added to their survival, there needs to be some kind of forum that lets them, if they chose to, record what they do after hPAM4. Some are going to go with standard of care, some will think outside the box and try other things. Oncologists have NO experience treating PC patients who have had their tumors exposed to radiation for a month from inside the tumor. No one knows exactly what happens inside those tumors. No one knows what compound might be able to work best in that damaged tumor and maybe maintain that response for a long time or maybe even improve it. As each responding patient picks his treatment path after hPAM4, they will be generating information with regard to how their tumor is responding. This could be very valuable information to PC patients who follow them. The three patients I communicate with would love to have a site to go to right now where a couple of hundred patients had been through this trial, responded and then went on to other treatment regimen's. They could sort through that information and rule out some approaches and narrow down the choices, maybe try two approaches together that seem to work to some degree alone, but no one has tried in combination. They could see the side effects of different approaches, albeit in a very limited sample, but still know what to look for if they went that route. The more information that can be generated by these patients and made available for following patients to use, the faster PC patients will find the path to maintenance of this horrible disease. The patients who are willing to do that (and pretty much anonymously) will certainly help those following them. The patients who want to keep it completely private have every right for that to be honored and respected. Getting hPAM4 approved and seeing it add significant quality of life months or years to PC lives is great, but it isn't good enough. There has to be a way to go from there and add even more quality months or years. If any of you out there see something interesting with regard to other compounds or approaches that appear to have some efficacy or positive effect on PC tumors, E-mail them to me or post them on here and I'll look into them and maybe pass them on to the guys. We've looked at quite a few and have a couple that are interesting enough that they are being shown to their oncologists, but one can always miss something. Happy Thanksgiving.