To: skinowski who wrote (13301 ) 2/6/2010 10:15:51 PM From: i-node 3 Recommendations Read Replies (4) | Respond to of 42652 >> In effect, higher US drug prices are a form of foreign aid. I understand this view but I'm not sure it really is like foreign aid. It may be in some instances. But let's take an example: Drug X has up front R&D costs of $100M, and fixed production costs of $25M. That is, these $125M costs are incurred regardless of whether it is sold in the US or worldwide. The variable cost to produce each dose of Drug X is $0.30, which includes the chemistry and packaging and other variable costs of production. But, the list price in the US is $2.00. So, for each dose they sell for $2.00 they have a net of $1.70 that can be applied to recovery of the fixed costs incurred in bringing the drug to market. Now, someone in Africa says, "Gosh, we could use that Drug X, but there is just no way we could be paying $2.00/dose; there just isn't that kind of money available. If you could sell if for $0.40 a dose, that would be different". So, the question is, "Should we sell the drug for $0.40/dose?" The answer, if course, is that EVERYONE wins if the drug company sells it for $0.40/dose versus just not doing anything. At $0.40, they recover $0.10 toward the fixed costs, money they're out anyway. Technically, they "lose money" on it, if full absorption costing is used (i.e., allocating a share of fixed costs to each dose). But those costs are "sunk", i.e., they've already been spent either way, so full costing isn't appropriate (accountants call this "incremental" costing, i.e., what is the cost to produce an "incremental" unit). To the extent the manufacturer can recover $0.10/dose (without increasing fixed production costs), it helps recover the sunk costs, which in the long run will reduce the cost of the drug to the American market OR will allow the manufacturer to recover the costs more quickly which means they'll be able to develop the next drug more quickly. The point is, that the drug manufacturer is able to get SOME contribution from the African market toward the fixed costs, which is better than just letting it pass, which is the alternative (because, no matter what, the African market can't pay $2.00/dose). Maybe that's foreign aid (foreign countries benefit) but it really isn't at OUR expense, and in fact, passing up on the $0.40/dose would be to OUR detriment.