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Biotech / Medical : Cistron Biotechnology(CIST)$.30 -- Ignore unavailable to you. Want to Upgrade?


To: James Silverman who wrote (903)11/6/1997 9:52:00 AM
From: Steve Harmon  Respond to of 2742
 
Jim,

Cash- $15 mil.
IL-1- $21 mil.

TOTAL-$36 mil.

Steve



To: James Silverman who wrote (903)6/30/1999 2:20:00 PM
From: Walter Morton  Respond to of 2742
 
Evidence That IL-1ß Mediates Bone Resorption

AA Sequence of Natural Osteoclast Activating Factor OAF=IL-1ß

IL-1ß induces bone resorption in vitro

IL-1ß elevated levels in gingival fluid correlate with severity of bone resorption

Osteoporosis in elderly patients is reduced with high spontaneous IL-1Ra production; vice versa

Blocking IL-1 receptors reduces spontaneous OAF activity in human myeloma cells

Soluble IL-1 receptors prevent OAF activity of conditioned media

Anti- IL-1ß antibodies (not anti-IL-1a) reduce Spontaneous OAF activity in human myeloma cells

emedtrade.com

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