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Biotech / Medical : Agouron Pharmaceuticals (AGPH) -- Ignore unavailable to you. Want to Upgrade?

To: Izzy who wrote (2686)	11/7/1997 3:52:00 PM
From: Joe E.	Respond to of 6136

News article on AIDS cocktails: "AIDS Cocktails Work in 'Real World,' Study Finds" Reuters (11/07/97); Reaney, Patricia New research published in the British Medical Journal suggests that AIDS cocktails are effective in prolonging lives and slowing the progress of HIV. The results are unique because they looked at the use of the drugs in the "real world" without the restrictions imposed in clinical drug trials. Overall, the Swiss researchers looked at the records of more than 5,000 HIV-infected patients treated at several Swiss hospitals and university AIDS units from 1988 to 1996. Data obtained from the records indicated that compared to patients who were not treated, patients experienced a 30 to 40 percent reduction in disease progression and death after two antiretroviral combination therapies were introduced in 1995, and a 60 percent reduction when triple therapy with protease inhibitors was initiated in 1996.

To: Izzy who wrote (2686)	11/7/1997 9:15:00 PM
From: Oliver & Co	Read Replies (1) \| Respond to of 6136

Hi Izzi, just back from the conference. Much new information. Good news and bad news. Unfortunately, no cure in sight. Vaccines 10 to 20 years away. New SHIV(Simian-Human Immunodeficiency Virus) made to do vaccine testing, pathogenic. Much failure seen with all types of therapy. Three important factors, CD45RO(memory)CD4 lymphocytes, "Beware the Sins of the Past," and adherence. From what I see, HIV/AIDS will be around for a long, long time. All the new coming drugs are more of the same,albeit improved. New viral load threshold @less than 20 copies. Patients who will do better will be those started on multi-drug cocktails, with perfect adherence. Treatment indefinetly. Proof of no resistance 2 years into treatment. No new drugs until mid-late 1998. DMP 266, Amprenavir, or 141 in phase III& 1592(Abacavir). JLL