To: J_F_Shepard who wrote (19011 ) 8/28/2010 6:40:32 PM From: Lane3 Read Replies (1) | Respond to of 42652 ""Have at it--statement of premise and supporting scientific data, if you please..."" You neglected to state the premise. The reason I specifically suggested that you do so was that it isn't clear from your original statement just what your premise is. Your original statement: "my primary... has adjusted my statin dose to reduce my LDL with a target of 70...my numbers are very close to that.... At that dose, plaque buildup is actually supposed to reverse.. ." The premise, as originally written, is not clear. Your statement, parsed, is that your dosage ("at that dose") is the dosage that will reverse plaque (possible premise1). I don't think you meant that. It's awkward to talk about a dosage reversing plaque. It makes more sense to talk about an LDL level reversing plaque and 70 is a common target mentioned in that context. So, given the context, I expect that you intended as your premise that getting LDL down to the 70 level is what's supposed to reverse atherosclerosis (possible premise 2). Given the lack of clarity, I left it open to give you the opportunity to pick whichever premise you had in mind. Or even to fiddle with the premise a bit if you needed some wiggle room to "revise and extend" your statement, as they say in Congress. But you didn't take the opportunity. If you don't state your premise, then how would you or anyone else know that you had found scientific data to support it? unless, of course, obfuscation is your strategy... Nonetheless, trudging ahead, I will evaluate the data you offered against each of your two possible premises. I was already familiar with the study you offered and knew when I selected that statement that REVERSAL wouldn't satisfy the premise. First of all, there's nothing in there about a LDL level of 70. Everyone in the study had LDL of 125-210 so that study is not applicable to possible premise 2. As for possible premise 1, if you were taking atorvastatin at a dosage of 80 mg, I'd give you a pass on a squeaker even though the reversal result wasn't statistically significant and the study is usually characterized as stabilizing but not regressing plaque. But you've told us what you're taking and that ain't it. So, bzzzz! No match. Do you want to try again? (Hint--I'm all but certain it would be futile.)