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Biotech / Medical : Incyte (INCY) -- Ignore unavailable to you. Want to Upgrade?

To: software salesperson who wrote (2668)	8/15/2011 9:39:58 PM
From: Biomaven	Respond to of 3202

JAK1 in cancer: ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma Summary To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. PDF 2.95 MB Export Citation Permissions Cancer Cell, Volume 20, Issue 2, 229-245, 16 August 2011 Copyright © 2011 Elsevier Inc. All rights reserved. 10.1016/j.ccr.2011.06.018 Authors Victoria Sanz-Moreno, Cedric Gaggioli, Maggie Yeo, Jean Albrengues, Fredrik Wallberg, Amaya Viros, Steven Hooper, Richard Mitter, Chloé C. Féral, Martin Cook, James Larkin, Richard Marais, Guerrino Meneguzzi, Erik Sahai, Chris J. MarshallSee Affiliations Highlights Cytokines signal via JAK1 to actomyosin contractility in tumor cells and stroma JAK1 signals to matrix remodelling in CAFs JAK1 signals to rounded/amoeboid movement of melanoma cells Round cells are found at invasive fronts of melanoma and stain for phospho-STAT3 Summary Proinflammatory cytokines are frequently observed in the tumor microenvironment, and chronic inflammation is involved in cancer initiation and progression. We show that cytokine signaling through the receptor subunit GP130-IL6ST and the kinase JAK1 generates actomyosin contractility through Rho-kinase dependent signaling. This pathway generates contractile force in stromal fibroblasts to remodel the extracellular matrix to create tracks for collective migration of squamous carcinoma cells and provides the high levels of actomyosin contractility required for migration of individual melanoma cells in the rounded, “amoeboid” mode. Thus, cytokine signaling can generate actomyosin contractility in both stroma and tumor cells. Strikingly, actomyosin contractility itself positively modulates activity of the transcription factor STAT3 downstream of JAK1, demonstrating positive feedback within the signaling network. For a discussion of this, see: Protein JAK Makes Cancer Cells Contract, So They Can Squeeze Out Of A Tumor medicalnewstoday.com